Document Type : Research Article
Authors
1
Chongqing Chemical Industry Vocational College, Chongqing, China
2
Shenyang Medical College, Shenyang, China
3
Shenyang Pharmaceutical University, Shenyang, China
4
-Department of Shanghai, Biomaterials department -Chongqing Chemical Industry Vocational College, Chongqing, China
5
School of Intelligent Medical Engineering, Sanquan College of Xinxiang Medical University, Xinxiang, 453003, China
10.30492/ijcce.2024.2014614.6287
Abstract
Gold nanoparticles (AuNPs) have garnered considerable interest in the field of medical research, particularly in the realm of cancer therapy, due to their exceptional optical and physical properties. These attributes make them highly promising candidates for a wide range of applications. An important advantage of AuNPs is their ability to be precisely engineered in terms of size and surface chemistry, facilitating targeted interactions with cancer cells and tissues. This study investigates the incorporation of Au-NPs into an alginate matrix for potential biomedical applications. The effects of Au-NPs on the biological properties, crystallinity, and morphology of the composite material are examined. Scanning Electron Microscopy (SEM) analysis reveals a homogeneous distribution of Au-NPs within the alginate matrix, with nanoparticle sizes ranging from 5 to 10 microns. At lower concentrations (5 wt% Au-NPs), the nanoparticles are well-dispersed and exhibit minimal agglomeration. However, at higher concentrations (10 wt% and 15 wt% Au-NPs), increased nanoparticle density leads to greater agglomeration. X-ray Diffraction (XRD) patterns demonstrate the highly crystalline nature of pure Au-NPs and the presence of additional diffraction peaks representing the alginate crystal structure in the composite material. These findings provide valuable insights into the structural characteristics and potential applications of the Au-NP-incorporated alginate matrix in biomedical fields. AuNPs possess the ability to selectively absorb and scatter light in a controlled manner, offering numerous possibilities for utilization. When exposed to specific wavelengths of light, AuNPs can generate localized heat, facilitating photothermal therapy. However, several challenges, such as ensuring safety, biocompatibility, improving targeting efficiency, and scaling up production, must be overcome to facilitate their translation into clinical use. Despite these obstacles, ongoing research efforts are focused on fully harnessing the potential of AuNPs for effective and personalized cancer treatments in the future.
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