Synthesis and Characterization of Targeted Magnetic Bentonite Nanohybrid for Enhanced Drug Delivery: A Promising Approach for Cancer Therapy

Articles in Press

Document Type : Research Article

Authors

1 School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, I.R. IRAN

2 2Department of Civil Engineering, Ohio University, Ohio, Athens 45701, USA

Abstract

The use of smart materials to deliver anticancer drugs to tumors has been considerably increased in cancer therapy. In this work, a novel pH-responsive system for drug delivery is proposed that employs magnetite nanoparticles and bentonite loaded with doxorubicin (DOX), a known anticancer drug, to investigate its loading capacity and release. This magnetic bentonite nanohybrid is first synthesized using a single-step method. The structural and spectral properties of the nano-assemblies are analyzed employing a variety of analytical methods including fourier transform infrared spectroscopy (FTIR), scanning and transmission electron microscopy (SEM and TEM, respectively), X-ray diffraction (XRD), and vibrating sample magnetometer (VSM). The drug-loading capacity, entrapment, and yield are compared with different ratios of 1:1, 1:2, and 1:4 of the drug: nanohybrid to choose the best ratio. Moreover, a pH-sensitive release is measured at pH 7.4 and 5.5 with a total release of 57% and 80% after 72 h, respectively. Considering all these findings, the magnetic bentonite shows significant promise as a potential candidate for drug delivery applications targeting cancer cells.

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Iranian Journal of Chemistry and Chemical Engineering

Articles in Press, Accepted Manuscript
Available Online from 23 December 2023

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