Bioanalytical and Theoretical Studies of the Spectrophotometrically Investigated Iridium (III)-3-Hydroxy-2-(4-Methoxyphenyl)-4H-Chromen-4-one Complex

Document Type : Research Article

Authors

1 Department of Chemistry, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala-13320, INDIA

2 Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala-133207, INDIA

3 Department of Human Genetics and Molecular Medicine, School of Health sciences, central University of Punjab, Bathinda-151401, INDIA

4 Department of Chemistry, Kurukshetra University, Kurukshetra

5 Department of Chemistry, Kurukshetra University, Kurukshetra-136119, INDIA

6 Department of Chemistry, Institute of H. Science, Dr. Bhimrao Ambedkar University, Agra-282002, UP, INDIA

7 Department of Physics, Aringnar Anna Govt. Arts College, Cheyyar-604407, INDIA

Abstract

A pioneering approach for the spectrophotometric inquisition of microscale amounts of iridium (III) under aqueous conditions has been explored using a novel benzopyran derivative, 3-hydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one (HMPC) as a ligand, hence, employing complexation as a basis of reaction between the two. The spontaneous complexation between iridium (III) and HMPC is manifested by the expeditious formation of a pale yellow complex at pH 4.87 in which the metal-to-ligand ratio [M:L] is estimated as 1:2. The complex absorbs paramountly at 423-430 nm and is markedly stable. For ensuring the formation of a stable complex, optimal conditions have been fixed concerning the parameters regulating its formation. Accordingly, the system shows coherence to linearity between 0.0-1.7 µg/mL of iridium (III). The molar attenuation coefficient and Sandell’s sensitivity are 6.824×104 L/mol cm and 0.00281µg Ir (III) cm-2, respectively at 425 nm. Statistical parameters including RSD, correlation coefficient (r), and detection limit are respectively, 0.2169%, 0.9999, and 0.0123 µg/mL. As a check for flexibility and usability of the method, intervention concerning complexing agents and cations of prime analytical importance has been carried out indicating the majority of these do not induce any interference during determination. The accomplished studies serve as proof of the versatility, flexibility, and sensitivity of the method. Keeping in view the aforesaid characteristics of the complex, it was subjected to numerous biological investigations and has been satisfyingly found to possess anti-cancerous, bactericidal, and antioxidant properties thus expanding its novel utility domain in the therapeutic world. Quantum chemical parameters (DFT and MEP), based on analysis of electronic properties of the complex in its most stable least energy conformation, are used to better understand the chemistry of the produced complex.

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References

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Iranian Journal of Chemistry and Chemical Engineering
Volume 42, Issue 10 - Serial Number 132
October 2023
Pages 3382-3397

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