Optimization of Atropine Extraction Process from Atropa Belladonna by Modified Bubble Column Extractor with Ultrasonic Bath

Document Type : Research Article


1 School of Chemical Engineering, College of Engineering, University of Tehran, P.O. Box 11155-4563 Tehran, I.R. IRAN

2 School of Chemical Engineering, University College of Engineering, University of Tehran, I.R. IRAN

3 Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, P.O. Box 31375-369 Karaj I.R. IRAN

4 Institute of Medicinal Plants, ACECR, Karaj, Iran


Modified Bubble Column Extraction with Ultrasonic Bath (BCE-UB) method was used to extract atropine from the stem and leaves of Atropa belladonna. Optimum condition were obtained with Kamada solvent which was chloroform-methanol-ammonia 15:15:1(v/v/v) as extraction solvent, the particle size of  less than  350 µm, an extraction time of 23.95 min, a liquor to material ratio of 15.08 mL/g and  an  air  flow of  6.31 mL/min.g. In this state, percent of extracted atropine was calculated which was equal to 6.81%. Percent of extracted atropine was 6.31% that showed a little difference compared to the predicted value. In order to study the effect of bubbles on the extraction rate, the same extraction with the previous method was performed in a stirred tank. Percent of atropine was 5.59%.


Main Subjects

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