One Pot Synthesis of Alpha-Aminonitrile and Alpha-Amino Acid From Schiff Bases

Document Type : Research Note


Department of Chemistry, Sharif University of Technology, P.O. Box 11365-9516 Tehran, I.R. IRAN



Addition of Potassium cyanide to a mixture of Schiff base and lithium perchlorate afforded a-aminonitriles in high yields. Addition of potassium cyanide to a methanolic solution of Schiff base and phosphoric acid afforded a-aminonitriles. When the reaction mixture was refluxed it gave a-amino acids in high yields.


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