Montmorillonite Nanocomposite Hydrogel Based on Poly(acrylicacid-co-acrylamide): Polymer Carrier for Controlled Release Systems

Document Type: Research Article

Authors

1 Department of chemistry, Arak Branch, Islamic Azad University, Arak, I.R. IRAN

2 Department of Chemistry, Payame Noor University, PO BOX 19395-3697, Tehran, I.R. IRAN

Abstract

In this paper, the synthesis of new montmorillonite nanocomposite hydrogel (MMTNH) based on poly (acrylic acid-co-acrylamide) grafted onto starch, is described. Montmorillonite (MMT) as nanometer base, acrylic acid (AA) and acrylamide (AAm) as monomers, ammonium persulfate (APS) as an initiator, N,N-methylenebisacrylamide (MBA) as a crosslinker and starch as a biocompatible polymer were prepared in aqueous solution and their amounts were optimized to attain the highest water absorbance. The optimized swelling capacity in distilled water was found to be 810 g/g. A mechanism for hydrogel formation was proposed and the structure of the product was confirmed using a set of techniques including FT-IR spectroscopy, thermogravimetric analysis, scanning electron microscopy, transmission electron microscopy, atomic force microscopy, and X-ray powder diffraction. Furthermore, the swelling behaviors of the nanocomposite at different pHs, various salt with different concentrations, the mixture of solvents, were investigated. The methylene blue (MB) dye was used as model drugs to assess the loading and release by MMTNH. The pH response of this MMTNH makes it suitable for acting as a controlled delivery system. The results suggest MMTNH may find applications as promising drug delivery vehicles for drug molecules.

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[1] Fan L-t., Singh S.K., Controlled Release:A Quantitative Treatment, Vol 13, “Springer Science & Business Media” (2012).

[2] Serizawa T., Matsukuma D., Akashi M., Loading and Release of Charged Dyes Using Ultrathin Hydrogels, Langmuir., 21(17): 7739-7742 (2005).

[3] Van der Linden H.J., Herber S., Olthuis W., Bergveld P., Stimulus-Sensitive Hydrogels and Their Applications in Chemical (micro) Analysis, Analyst., 128(4): 325-331(2003).

[4] Bennett S.L., Melanson D.A., Torchiana D.F., Wiseman D.M., Sawhney A.S., Next‐Generation HydroGel Films as Tissue Sealants and Adhesion Barriers, Journal of Cardiac Surgery, 18 (6): 494-499 (2003)

[5] Gupta P., Vermani K., Garg S., Hydrogels: from Controlled Release to pH-Responsive Drug Delivery, Drug Discovery Today., 7(10): 569-579 (2002).

[6] Qiu Y., Park K., Environment-Sensitive Hydrogels for Drug Delivery, Advanced Drug Delivery Reviews., 53(3): 321-339 (2001).

[7] Guilherme M.R., Reis A.V., Takahashi S.H., Rubira A.F., Feitosa J.P., Muniz E.C., Synthesis of a Novel Superabsorbent Hydrogel by Copolymerization of Acrylamide and Cashew Gum Modified with Hlycidyl Methacrylate, Carbohydrate Polymers.,61(4): 464-471 (2005).

[8] Bardajee G.R., Mizani F., Hosseini S.S., pH Sensitive Release of Doxorubicin Anticancer Drug from Gold Nanocomposite Hydrogel Based on Poly (Acrylic Acid) Grafted onto Salep Biopolymer, Journal of Polymer Research., 24(3): 24-48 (2017).

[9] Young C-D., Wu J-R., Tsou T-L., Fabrication and Characteristics of polyHEMA Artificial Skin with Improved Tensile Properties, Journal of Membrane Science., 146(1): 83-93 (1998).

[10] Abusafieh A., Siegler S., Kalidindi SR., Development of Self‐Anchoring Bone Implants. I. Processing and Material Characterization, Journal of Biomedical Materials Research., 38(4): 314-327 (1997).

[11] Mahdavinia G.R., Marandi G.B., Pourjavadi A., Kiani G., Semi‐IPN Carrageenan‐Based Nanocomposite Hydrogels: Synthesis and Swelling Behavior, Journal of Applied Polymer Science., 118(5): 2989-2997 (2010).

[12] Zhou C., Wu Q., A novel Polyacrylamide Nanocomposite Hydrogel Reinforced with Natural Chitosan Nanofibers, Colloids and Surfaces B: Biointerfaces., 84(1): 155-162 (2011).

[13] Zhang Y-T., Zhi T-T., Zhang L., Huang H., Chen H-L., Immobilization of Carbonic Anhydrase by Embedding and Covalent Coupling into Nanocomposite Hydrogel Containing Hydrotalcite, Polymer., 50(24): 5693-5700 (2009).

[14] Wang Y., Chen D., Preparation and Characterization of a Novel Stimuli-Responsive Nanocomposite Hydrogel with Improved Mechanical Properties, Journal of Colloid and Interface Science., 372(1): 245-251 (2012).

[15] Satarkar N.S., Hilt J.Z., Hydrogel Nanocomposites as Remote-Controlled Biomaterials, Acta Biomaterialia., 4(1): 11-16 (2008).

[16] Li P, Dou X-Q., Tang Y-T., Zhu S., Gu J., Feng C-L., Zhang D., Gelator-Polysaccharide Hybrid Hydrogel for Selective and Controllable Dye Release, Journal of Colloid and Interface Science., 387(1): 115-122 (2012).

[18] Nagai Y., Unsworth LD., Koutsopoulos S., Zhang S., Slow Release of Molecules in Self-Assembling Peptide Nanofiber Scaffold, Journal of Controlled Release., 115(1): 18-25 (2006).

[20] Pavlidoua S., Papaspyrides C.D., A Review on Polymer–Layered Silicate Nanocomposites, Prog. Polym. Sci., 33(12): 1119-1198 (2008).

[21] Mojtaba S., Narmin B.A., Mohammad S.H., Fateme Z., Mostafa Y., Synthesis and Properties of Plasticized Sulfur-Montmorillonite Nanocomposites by Melt-Blending, Iranian Journal of Chemistry and Chemical Engineering (IJCCE), 36(6): 1-9 (2017).

[22] Luo W., Zhang W.A., Chen P., Fang Ye., Synthesis and Properties of Starch Grafted Poly [acrylamide‐co‐(acrylic acid)]/montmorillonite Nanosuperabsorbent via γ‐Ray Irradiation Technique, Journal of Applied Polymer Science., 96(4): 1341-1346 (2005).

[23] Mohammad K., Ali N., Montmorillonite Nanoparticles in Removal of Textile Dyes from Aqueous Solutions: Study of Kinetics and Thermodynamics, Iranian Journal of Chemistry and Chemical Engineering (IJCCE), 36(6): 127-137 (2017).

[25] Pourjavadi A., Jahromi PE., Seidi F., Salimi H., Synthesis and Swelling Behavior of Acrylatedstarch-g-Poly (Acrylic Acid) and Acrylatedstarch-g-Poly (Acrylamide) Hydrogels, Carbohydrate Polymers 79(4): 933-940 (2010).

[26] Chen J., Zhao Y., Relationship between Water Absorbency and Reaction Conditions in Aqueous Solution Polymerization of Polyacrylate Superabsorbents, Journal of Applied Polymer Science., 75(6): 808-814 (2000).

[27] Kabiri K., Zohuriaan‐Mehr M., Superabsorbent Hydrogel Composites, Polymers for Advanced Technologies., 14(6): 438-444 (2003).

[28] Omidian H., Hashemi S., Sammes P., Meldrum I., A Model for the Swelling of Superabsorbent Polymers, Polymer., 39(26): 6697-6704 (1998).

[29] Elvira C., Mano J., San Roman J., Reis R., Starch-Based Biodegradable Hydrogels with Potential Biomedical Applications as Drug Delivery Systems, Biomaterials., 23(9): 1955-1966 (2002).

[30] Pass G., Phillips G., Wedlock D., Interaction of Univalent and Divalent Cations with Carrageenans in Aqueous Solution, Macromolecules., 10(1): 197-201 (1977).

[31] Rosiak JM., Yoshii F., Hydrogels and Their Medical Applications, Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms., 151(1): 56-64 (1999).

[32] Jianqi F., Lixia G., Swelling/Deswelling Behavior of Thermally Induced PVA/PAA Hydrogel Fiber in Aqueous Salt Solutions, Journal of Polymer Materials, 19(1): 103-112 (2002).

[33] Pourjavadi A., Bardajee G.R., Soleyman R., Synthesis and Swelling behavior of a New uperabsorbent Hydrogel Network Based on Polyacrylamide Grafted onto Salep, Journal of Applied Polymer Science., 112(5): 2625-2633 (2009).‏

[34] Zohuriaan‐Mehr M., Motazedi Z., Kabiri K., Ershad‐Langroudi A., Allahdadi I., Gum Arabic–Acrylic Superabsorbing Hydrogel Hybrids: Studies on Swelling Rate and Environmental Responsiveness, Journal of Applied Polymer Science., 102(6): 5667-5674 (2006).

[35] Bardajee G.R., Pourjavadi A., Ghavami S., Soleyman R., Jafarpour F., UV-Prepared Salep-Based Nanoporous Hydrogel for Controlled Release of Tetracycline Hydrochloride in Colon, J. Photo. Biol., 102(3): 232-240 (2011).