Comparison of Catalytic Effect of Alkali and Alkaline Earth Metals Hydrogen Sulfate: As the Promoter for an Efficient Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones under Solvent-Free Conditions

Document Type : Research Article

Authors

Department of Chemistry, Shahid Beheshti University, P. O. Box 19396-4716, Tehran, I.R. IRAN

Abstract

Alkali and alkaline earth metals hydrogen sulfate catalyzed the one-pot three component condensation reactions of aldehydes, 1,3-dicarbonyl compounds and urea or thiourea under solvent-free conditions leading to 3,4-dihydropyrimidin-2(1H)-ones in high yields at 80 °C. Our results showed that Biginelli reaction not only is pH dependent, but the cation of catalyst plays an important role. 

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References

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Iranian Journal of Chemistry and Chemical Engineering
Volume 24, Issue 3 - Serial Number 35
September 2005
Pages 67-71

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