Volumetric and Viscometric Studies of Nucleosides, Nucleotides and Furanose Sugar in Aqueous Medium from 288.15 to 298.15K

Document Type : Research Article


Chemistry Research Laboratory, Deshbandhu College, University of Delhi, New Delhi-110019, INDIA


Density (r/g cm-3) and viscosity (h/10-2gcm-1s-1=1centipoise,CP) of guanosine monophosphate (GMP) and adenosine triphosphate (ATP) referred to as nucleotide, and 2-deoxy adenosine (DOA) and thymidine (TMD) as nucleoside along with their integral furanose sugar, 2-deoxy ribose (DOR) from 0.0004 to 0.0014mol kg-1 solution have been measured at 288.15, 293.15 and 298.15K at atmospheric pressure. The r was fitted into the Masson and h in Jones-Dole equationsfor apparentmolal volume  (Vf/cm3mol-1)  and  viscositycoefficient((hr-1)/m=B/kg mol-1=103gmol-1) data. The Vfand h werealso regressed forV0f and h0 values known as the limiting constants and illustrate solute-solvent and solute-solutein teractions of systems. The apparent molal volume of their various integral units like adenine, guanine and thymine of nucleotides and nucleosidesareestimatedbyV0fTheV0fh0andB values have been used to elucidate the hydrophilic and hydrophobic interactions. The V0f values are negative over the whole range of the compositions which infer greater intermolecular forces and the biomolecules as water structure breakers.


Main Subjects

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