Four Components One-Pot Synthesis of New Thiazoles and Their Biological Screening for Anti-Tuberculosis Activity

Document Type : Research Article

Authors

1 Department of Chemistry, Maulana Azad College of Arts, Science and Commerce, Aurangabad-431 003, INDIA

2 Department of Chemistry, Vivekanand ArtsSardar Dalipsingh Commerce and Science College, Aurangabad, Maharashtra 431 001, INDIA

Abstract

Multi heterocyclic ring system shows a wide spectrum of pharmaceutical and biological activities. Novel series of 2-Benzyloxy-5-(2-{N'-[3-(substituted-phenyl)-1-phenyl-1H-pyrazol-4-ylmethylene]-hydrazino}-thiazol-4-yl)-benzoic acid methyl ester derivatives have been synthesized by one-pot condensation of 2-Benzyloxy-5-(2-bromo-acetyl)-benzoic acid methyl ester, thiosemicarbazide and 3-(substituted-phenyl)-1-phenyl-1H-pyrazole-4-carbaldehyde using orthophosphoric acid as a catalyst under mild reaction condition. All the synthesized compounds were screened for their anti-tubercular activity against Mycobacterium tuberculosis H37Rv stains using the Lowenstein-Jensen (L. J.) medium conventional method. Most of these synthesized compounds are found to be active potent against Mycobacterium tuberculosis H37Rv strain. Environmentally benign, multicomponent, rapid, high atom and step economy, facile are the remarkable features
of the present one-pot multicomponent protocol.

Keywords

Main Subjects

References

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Iranian Journal of Chemistry and Chemical Engineering
Volume 42, Issue 9 - Serial Number 131
September 2023
Pages 2840-2847

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