An exclusive approach towards the synthesis of indoylquinoline alkaloids has been illustrated, the present article describes the synthesis, in Platelet-derived growth factor receptor and silico molecular docking studies of a new compound 3-indolylquinoline-2,4-diol 4. The synthesis of 4 is initiated by a new, efficient, and solvent-free via a thermal Claisen condensation. The structures of the compounds are established using both spectral and analytical data. An in-silico PASS, Swiss ADME-assisted docking approach is found to be suitable for deriving and synthesizing effective receptor tyrosine kinase agents. Claisen ester condensation reaction resulted in the discovery of inexpensive and user-friendly solvents. Structures of the newly synthesized compounds were characterized by FT-IR, 1H NMR, 13C NMR, and HRMS (FTMS+PESI) analyses.
Vijayarathinam, M., Kannan, A., Akilan, P., Chanrasekaran, V., & Gunasekaran, T. (2023). Synthesis and in Silico Studies of Novel Potent Kinase Inhibitors: 3-Indoloylquinoline Alkaloid. Iranian Journal of Chemistry and Chemical Engineering, 42(8), 2505-2514. doi: 10.30492/ijcce.2022.559177.5475
MLA
M. Vijayarathinam; A. Kannan; P. Akilan; V. Chanrasekaran; T. Gunasekaran. "Synthesis and in Silico Studies of Novel Potent Kinase Inhibitors: 3-Indoloylquinoline Alkaloid". Iranian Journal of Chemistry and Chemical Engineering, 42, 8, 2023, 2505-2514. doi: 10.30492/ijcce.2022.559177.5475
HARVARD
Vijayarathinam, M., Kannan, A., Akilan, P., Chanrasekaran, V., Gunasekaran, T. (2023). 'Synthesis and in Silico Studies of Novel Potent Kinase Inhibitors: 3-Indoloylquinoline Alkaloid', Iranian Journal of Chemistry and Chemical Engineering, 42(8), pp. 2505-2514. doi: 10.30492/ijcce.2022.559177.5475
VANCOUVER
Vijayarathinam, M., Kannan, A., Akilan, P., Chanrasekaran, V., Gunasekaran, T. Synthesis and in Silico Studies of Novel Potent Kinase Inhibitors: 3-Indoloylquinoline Alkaloid. Iranian Journal of Chemistry and Chemical Engineering, 2023; 42(8): 2505-2514. doi: 10.30492/ijcce.2022.559177.5475
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