Synthesis and Drug Delivery Evaluation of Graphene Oxide Supported 5-Fluorouracil

Document Type : Research Article

Authors

1 Department of Chemistry, Ahvaz Science and Research Branch, Islamic Azad University, Ahvaz, I.R. IRAN

2 Department of Chemistry, Shiraz Branch, Islamic Azad University, Shiraz, I.R. IRAN

3 Advanced Surface Engineering and Nano Materials Research Center, Department of Chemistry, Ahvaz Branch, Islamic Azad University, Ahvaz, I.R. IRAN

4 Department of Chemistry, Ahvaz Branch, Islamic Azad University Ahvaz, I.R. IRAN

Abstract

A novel 5-fluorouracil and graphene oxide [GO-5-FU] mediated drug delivery system was prepared that involves uniquely combining Graphene Oxide (GO) with anticancer 5-fluorouracil (5-FU) drug for controlled drug release. The nanocarrier system was synthesized by attaching 5-FU to graphene oxide via a strong π–π stacking interaction. The loading and release of 5-FU   indicated strong pH dependence and implied hydrogen-bonding interaction between graphene oxide and 5-fluorouracil. The [GO-5-FU] system increased significantly in acidic pH and higher temperature without any burst release. In addition, the equilibrium adsorption data were analyzed by the Langmuir and Freundlich models. The results showed that the adsorption behavior could be fitted better by the Freundlich model. We believe that these materials and pH-dependent properties allow developments in controlled drug release techniques for biological and biomedical applications. It is obtained that about 66% of 5-FU was released in the simulated intestinal fluid (pH 7.4) at 37◦C over a period of 30 h, while at this temperature and pH environment of the gastric fluid (pH 1.2), ltngvk.tyn 5 5-FU was released approximately 90% over a period of 30 h. At 37◦C and this period of time, the amount of 5-FU release was 78% at pH 10. As can be observed, as the temperature is raised, the release of 5-FU is increased.

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Iranian Journal of Chemistry and Chemical Engineering
Volume 42, Issue 4 - Serial Number 126
April 2023
Pages 1134-1146

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