Document Type : Research Article
Department of Chemistry, Karaj Branch, Islamic Azad University, Karaj, I.R. IRAN
Chemistry Department, Payame Noor University, Tehran, I.R. of IRAN
In the present study, the loading and releasing of Diclofenac Sodium (DS) were investigated using a pH-sensitive magnetic nanocomposite hydrogel. The hydrogel was prepared through grafting copolymerization of Acrylic Acid (AA) and acrylamide (AAm) and using ammonium persulfate (APS) as a free radical initiator in the presence of Fe3O4@SiO2@ (3-Aminopropyl) trimethoxysilane (APTMS)@Maleic anhydride (MAN) as a cross-linker. The nanocomposite hydrogel structure (Fe3O4@SiO2@APTMS@MAN) was confirmed as the result of XRD, VSM, FT-IR, SEM, EDS, and TEM spectroscopy techniques. Furthermore, thermal properties were deliberated using TGA and DTG. The effects of different parameters such as pH, time, Fe3O4@SiO2@APTMS@MAN content, and salt solutions on swelling behavior were investigated considering the abovementioned outcomes. The adsorption isotherm was studied at 25°C using Langmuir, Freundlich, and Temkin. The adsorption data were well described by the Langmuir isotherm model. A kinetic study revealed the applicability of pseudo-first-order and pseudo-second-order models for the adsorption of mentioned DS. Moreover, the pH sensitivity of nanocomposite hydrogel and loading/releasing drugs were studied. Examining in vitro drug release in different buffer solutions indicated that the pH of the solution could mainly lead to the DS drug-releasing behavior of hydrogel. However, the cumulative release ratio of DS in pH: 7.4 solutions reached up to 93% within 120 min. Consequently, the investigated nanocomposite hydrogel of this study (Fe3O4@SiO2@APTMS@MAN) can be applied in widespread biomedical applications, particularly for controlled, targeted drug delivery purposes.