Synthesis, Molecular Docking and Anticancer Activity of Novel (E)-5-((1-phenyl-1H-1,2,3-triazol-4-YL)Methylene)-2-thioxothiazolidin-4-one Analogues

Document Type : Research Article

Authors

New Generation Materials Lab (NGML), Department of Science if Humanities, Vignan’s Foundation for Science Technology and Research (VFSTR) University, Vadlamudi, Guntur, Andhra Pradesh-522213, INDIA

Abstract

A novel series of (E)-5-((1-Phenyl-1H-1,2,3-triazol-4-yl)methylene)-2-thioxothiazolidin-4-one analogues were designed for anticancer activity and synthesized by the reaction of 1-Aryl-1H-1,2,3-triazole-4-carbaldehydes with 2-thioxothiazolidin-4-one. The synthesized compounds were analyzed by IR, 1HNMR, 13CNMR, and mass spectrometry. The compounds were screened for in vitro anticancer activity using four cancer cell lines viz. Lung (A549), Colon (HT-29), Breast (MCF-7), and Melanoma (A375), resulted from most of the compounds showed moderate to better activity against all cell lines, among them the compounds 6g and 6j were the most potent in all investigated cancer cell lines (lung, colon, breast, and melanoma. The compounds were studied in molecular docking studies, which resulted in a significant dock score shown with all the compounds. The compounds 6i and 6b have shown the highest dock scores.

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References

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Iranian Journal of Chemistry and Chemical Engineering
Volume 40, Issue 6 - Serial Number 110
November and December 2021
Pages 1793-1799

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