Electrochemical Determination Venlafaxine at NiO/GR Nanocomposite Modified Carbon Paste Electrode

Document Type : Research Article


1 Department of Clinical Laboratory, Al Zahra Hospital, Isfahan University of Medical Sciences, Isfahan, I.R. IRAN

2 Department of Chemistry, University of Isfahan, Isfahan, I.R. IRAN

3 Department of Chemistry, Payame Noor University, Tehran, I.R. IRAN


The electro-oxidation of venlafaxine (VEN) was investigated at a carbon paste electrode, the modified electrode by NiO/graphene reduce (GR) nanocomposite. The structure and morphological aspects of the nanocomposite were approved using FE-SEM, EDAX, and FT-IR. The electrode reaction process was a diffusion-controlled one and the electrochemical oxidation involved two electrons transferring and two protons participating. Under the optimized conditions, the electro-oxidation peak currents were linearly dependent on the concentration of VEN in the concentration range from 1.0- 40.0 μM with the limit of detection (S/N=3) as 0.05 μM. The proposed method has been successfully applied in the electrochemical quantitative determination of VEN content in real samples and the determination, results could meet the requirement of the quantitative determination.


Main Subjects

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