Synthesis and Characterization of γ[email protected]@β-CD Core-Shell Nanoparticles as a Novel Magnetic Nanoreactor and Its Application in the One-Pot Preparation of β-azido Alcohols, β-nitro Alcohols, and β-cyanohydrins

Document Type : Research Article


1 Chemistry Department, College of Science, Shahid Chamran University, Ahvaz 61357-4-3169, I.R. IRAN

2 ACECR-Production Technology Research Institute, Ahvaz, I.R. IRAN


In this study, β-cyclodextrin(β-CD) supported, hydroxyapatite encapsulated γ-Fe2O3 (γ-Fe2O3@[email protected]β-CD) was successfully prepared and evaluated as a solid-liquid phase transfer catalyst and also a molecular host system and nanoreactor for the nucleophilic ring-opening of epoxides in water for the preparation of β-azido alcohols, β-nitro alcohols, and β-cyanohydrins. The catalyst was characterized by FT-IR, XRD, TGA, and SEM. This procedure offers several advantages including excellent regioselectivity, high yields, short reaction times, recyclable catalyst, easy separation of the catalyst through external magnet, and easy work-up.


Main Subjects

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