Two New Cholinesterase Inhibitory and Antioxidative Constituents from Syzygium cumini

Document Type : Research Article


1 Institute of Chemical sciences, Gomal University, D I Khan, KPK, PAKISTAN

2 Department of Chemistry, FBS, Balochistan University of Information Technology, Engineering and Management Sciences, Takatu Campus, PAKISTAN

3 Institute of Chemical Sciences, Gomal University, D I Khan, KPK, PAKISTAN


Phytochemical investigation on dichloromethane (CH2Cl2) fraction from fruit seeds of Syzygium cumini provided two new esters Syzygioate A (1) and Syzygioate B (2), along with known compounds dipropyl succinate and dioctyl phthalate. The isolated compounds were characterized via spectroscopic techniques such as 1H, 13C NMR, EI-MS spectrometry, and FT-IR. The bioassay studies were also conducted for the isolated compounds where the new compound 1 and 2 exhibited significant inhibition potential against acetylcholinesterase (AChE), butylcholinesterase (BChE) & antioxidant activity against Diammonium 2,2'- azino -bis (3-ethyl benzo thiazoline-6-sulfonic acid (ABTS), superoxide anion radical scavenger & 2,2-di phenyl-1-picryl hydrazyl (DPPH). The IC50 values of compounds 1 and 2 for their cholinesterase inhibition were 7.15, 4.54µM against AChE, and 9.21 & 6.31µM against BChE. The DPPH radical scavenging potential for compounds 1 & 2 exhibited IC50 values as 69.4µg/ml and 74.6µg/ml respectively.


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