Magnetically Responsive Nanocomposite Hydrogels for Controlled Release of Ciprofloxacin

Document Type : Research Article


1 Prince Sattam Bin Abdulaziz University, Faculty of Science and Humanities, Hawtat Bani Tamim, SAUDI ARABIA

2 Polymer Chemistry Department, National Center for Radiation Research and Technology, Egyptian Atomic Energy Authority, Cairo, EGYPT

3 Department of chemistry, Faculty of Science, Minofia University, EGYPT


Despite the huge work concerning the applicability of polymeric hydrogels in the field of drug release, it is still a promising and interesting area for more improvements and trials for preparing newly designed drug delivery systems. In this study, acrylamide and hydroxyl ethyl methacrylate (HEMA) copolymer hydrogels were prepared with the aid of gamma radiation, and the P(AAM/HEMA) nanocomposite hydrogels were obtained by in situ absorption and reduction method of iron salts and silver nitrates (AgNO3) to form P(AAM/HEMA)-Fe3O4 and P(AAM/HEMA)-Ag nanocomposites. The prepared hydrogels and the formed nanoparticles were studied by various techniques; FT-IR, TEM, SEM, and the gel content and swelling behavior were evaluated. FT-IR confirmed the high interaction, which resulted in the successful formation of the AAm/HEMA copolymer hydrogel. TEM provides a good evaluation of the size of the formed Fe3O4 and Ag NPs  to be 12 and 8.5 nm respectively. The prepared hydrogels and nanocomposite hydrogels were examined as drug delivery systems for Ciprofloxacin HCl as a model drug. The results showed that PAM/HEMA-Fe3O4 nanocomposite gave the suitable load and release behavior towards Ciprofloxacin HCl.


Main Subjects

[1] Ghasemzadeh H., Ghanaat F., Antimicrobial Alginate/PVA Silver Nanocomposite Hydrogel, Synthesis and Characterization, J. Polym. Res., 21 (2014).
[2] Zhou Y., Zhao Y., Wang L., Xu L., Zhai M., Wei S., Radiation Synthesis and Characterization of Nanosilver/Gelatin/Carboxymethyl Chitosan Hydrogel, Radiat Phys Chem ., 81: 553–560 (2012).
[3] Juby K.A., Dwivedi C., Kumar M., Kota S.  Misra H. S., P N Bajaj P. N., Silver Nanoparticle-Loaded PVA/Gum Acacia Hydrogel: Synthesis, Characterization and Antibacterial Study, Carbohydr Polym., 89:906–913 (2012).
[4] Deen G., Chua V., Synthesis and Properties of New “Stimuli” Responsive Nanocomposite Hydrogels Containing Silver Nanoparticles, Gels, 1: 117–134 (2015).
[5] Abou El Fadl F.I., Maziad N.A., El-Hamouly S.H., Hassan H.R., Synthesis and Characterizations of Various Polyvinyl Pyrrolidone/Hydroxyl Ethyl Methacrylate Nanocomposite Hydrogels as Drug Delivery Systems, J. Macromol Sci Part A Pure Appl Chem., 55:107–115 (2018).
[6] Dai Q.Q., Ren J.L., Peng F., Chen X.F., Gao C.D., Sun R.C., Synthesis of Acylated Xylan-Based Magnetic Fe3O4 Hydrogels and their Application for H2O2 detection. Materials (Basel) 9 (2016).
[7] Raju A.N.P.K.M., Development of Guar Gum based Magnetic Nanocomposite Hydrogels for the Removal of Toxic Pb2+ Ions from the Polluted Water, Int J Sci Res., 5: 1588–1595 (2016).
[8] Rashid A., Ahmad M., Tulain U. R., Iqbal F. M., Fabrication and Evaluation of 2-hydroxyethyl Methacrylate-Co-Acrylic Acid Hydrogels for Sustained Nicorandil Delivery, Trop J Pharm Res., 14: 1121–1128 (2015).
[9] Ferreira L., Vidal M. M., Gil M. H., Design of a Drug-Delivery System Based On Polyacrylamide Hydrogels, Evaluation of Structural Properties. Chem Educ., 6: 100–103 (2001).
[10] Bashir S., Teo Y.Y., Naeem S., Ramesh S., Ramesh K., pH responsive N-Succinyl Chitosan/Poly (Acrylamide-co-acrylic acid) Hydrogels and in Vitro Release of 5-Fluorouracil, PLoS One., 12: 1–24 (2017).
[11] Torres-Figueroa A. V., Pérez-Martínez C. J., Castillo-Castro T. Del., Bolado-Martínez E., Corella-Madueño M.A.G., García-Alegría A.M., Lara-Ceniceros T.E., Armenta-Villegas L., Composite Hydrogel of Poly(acrylamide) and Starch as Potential System for Controlled Release of Amoxicillin and Inhibition of Bacterial Growth, J Chem. (2020).
[12] Sana S.S., Arla S.K., Badineni V., Boya V.K.N., Development of Poly (acrylamide-co-diallyldimethylammoniumchloride) Nanogels and Study of their Ability As Drug Delivery Devices, SN Appl Sci., 1:1–10 (2019).
[13] Tanasa E., Zaharia C., Radu I. C., Surdu V. A., Vasile B.S., Damian  C.M., Andronescu E., Novel Nanocomposites Based on Functionalized Magnetic Nanoparticles and Polyacrylamide: Preparation and Complex Characterization, Nanomaterials, 9(10): 1384 (2019).
[14] Baghban A., Jabbari M., Rahimpour E., Fe3O4@Polydopamine Core-Shell Nanocomposite as a Sorbent for Efficient Removal of Rhodamine B from Aqueous Solutions: Kinetic and Equilibrium Studies, Iran. J. Chem. Chem. Eng. (IJCCE), 37: 17–28 (2018).
[15] Mahmoud M.M., Abou El Fadl F.I., Mohamed M.A., Ibrahim S.M., Improvement of hydrophilicity of Natural Rubber Latex/Potato-Starch blend by grafting with Hydrophilic Monomers, Iran Polym J., (2021).
[16] Asadi S., Eris S., Azizian S., Alginate-Based Hydrogel Beads as a Biocompatible and Efficient Adsorbent for Dye Removal from Aqueous Solutions, ACS Omega., 3: 15140−15148 (2018)
[17] Sabnam T., Monir B., Afroz S., Khan R.A., Miah M.Y., Takafuji M., Alam M. A., pH-Sensitive Hydrogel from Polyethylene Oxide and Acrylic Acid by Gamma Radiation, J. Compos. Sci., 3: 58 (2019)
[18] Ibrayeva Z., Blagikh E., Kudaibergenov S., Introduction II Mechanical Properties of Composite Hydrogel Materials Based on Poly ( Acrylamide ) and Clay Minerals and their Potential Application for Cleaning of the Internal Surface of Pipes, Advances in Engineering Mechanics and Materials., 001(2003).
[19] Ranathunge T.A., Karunaratne D.G.G.P., Rajapakse R.M.G., Watkins D.L., Doxorubicin Loaded Magnesium Oxide Nanoflakes as pH Dependent Carriers for Simultaneous Treatment of Cancer and Hypomagnesemia, Nanomaterials., 9 (2019).
[20] Keirouz A., Radacsi N., Ren Q., Dommann A., Beldi G., Maniura‑Weber K., Rossi R. M., Fortunato G., Nylon-6/chitosan Core/Shell Antimicrobial Nanofibers for the Prevention of Mesh-Associated Surgical Site Infection, J. Nanobiotechnology., 18: 1–17 (2020).
[21] Motaali S., Pashaeiasl M., Akbarzadeh A., Davaran S., Synthesis and Characterization of Smart N-Isopropylacrylamide-Based Magnetic Nanocomposites Containing Doxorubicin Anti-Cancer Drug, Artif Cells, Nanomedicine Biotechnol., 45: 560–567 (2017).
[22] Abd El-Hady M.M., El-Sayed Saeed S.E.S., Antibacterial Properties and pH Sensitive Swelling of Insitu Formed Silver-Curcumin Nanocomposite Based Chitosan Hydrogel, Polymers., (Basel) 12: 1–14 (2020).
[23] Madduma-Bandarage U.S.K., Madihally S.V., Synthetic Hydrogels: Synthesis, Novel Trends, and Applications, J. Appl. Polym. Sci., 138: 1–23 (2021).
[24] Tanan W., Saengsuwan S., Microwave Assisted Synthesis of Poly (acrylamide-co-2-hydroxyethyl methacrylate)/poly(vinyl alcohol) Semi-IPN Hydrogel, Energy Procedia., 56: 386–393 (2014)
[25] Reowdecha M., Dittanet P., Sae-oui P., Loykulnant S.,  Prapainainar P., Film and Latex Forms of Silica-Reinforced Natural Rubber Composite Vulcanized Using Electron Beam Irradiation, Heliyon., 7: e07176 (2021)
[26] Zhang C., Easteal A. J., Study of Poly(acrylamide-co-2-acrylamido-2-methylpropane Sulfonic Acid) Hydrogels Made Using Gamma Radiation Initiation, J. Appl. Polym. Sci., 89:1322–1330 (2003).
[27] Abou El Fadl F. I., Elbarbary A. M., Radiation Synthesis And Characterization of Heterogeneous Magnetic Nanocomposites of 2-Hydroxyethyl Methacrylate for Catalytic Degradation of Sandocryl Blue Dye, Sep Purif Technol., 272: 118972 (2021).
[28] Micutz M., Lungu R. M., Circu V., Ilis M., Staicu T., Hydrogels obtained via γ-irradiation Based on Poly(Acrylic Acid) And its Copolymers with 2-Hydroxyethyl Methacrylate, Appl Sci., 10: 4960 (2020).
[29] Eid M., Gamma Radiation Synthesis and Characterization of Starch Based Polyelectrolyte Hydrogels Loaded Silver Nanoparticles, J. Inorg Organomet Polym Mater., 21: 297–305 (2011)
[30. Budianto E., Muthoharoh S. P., Nizardo N. M., Effect of Crosslinking Agents , pH and Temperature on Swelling Behavior of Cross - linked Chitosan Hydrogel, Asian J Appl Sci., 03: 2321–893 (2015)
[31] Davaran S., Alimirzalu S., Nejati-Koshki K.,  Nasrabadi H.T., Akbarzadeh A., Khandaghi A.A., Abbasian M., Alimohammadi S., Physicochemical Characteristics of Fe3O4 Magnetic Nanocomposites Based on Poly(N-isopropylacrylamide) for Anti-Cancer Drug Delivery, Asian Pacific J Cancer Prev., 15:49–54 (2014).
[32] Bayandori Moghaddam  A., Hosseini S., Badraghi J., Banaei A., Hybrid Nanocomposite Based on CoFe2 O4 Magnetic Nanoparticles and Polyaniline, Iran. J. Chem. Chem. Eng. (IJCCE), 29(4):173–179(2010).
[33] Anda-Flores Y.D., Carvajal-Millan E., Campa-Mada  A., Lizardi-Mendoza J., Rascon-Chu A., Tanori-CordovaJ.,  Martínez-López A. L., Polysaccharide-Based Nanoparticles for Colon-Targeted Drug Delivery Systems. Polysaccharides., 2(3): 626-647 (2021).
[34] Henríquez C. M. G., del Carmen Pizarro Guerra G., Vallejos M.A.S., Rojas de la Fuente S.D., Flores M.T.U., Jimenez L. M. R., In Situ Silver Nanoparticle Formation Embedded into a Photopolymerized Hydrogel with Biocide Properties, J. Nanostructure Chem., 4: 119–132 (2014)