Sodium Alginate/Starch Blends Loaded with Ciprofloxacin Hydrochloride as a Floating Drug Delivery System - In Vitro Evaluation

Document Type : Research Article


Materials Chemistry Division, School of Advanced Sciences, VIT University, Vellore, Tamil Nadu-632014, INDIA


In the present study, Floating Drug Delivery Beads (FDDS) were prepared with sodium alginate/ starch blend as a matrix, sodium hydrogen carbonate as a pore forming agent, methyl cellulose as a binder and barium chloride solution as a hardening agent. In order to prepare the beads with different porosity and morphology the ratio between pore forming agent to polymer blend and ratio of the constituents of the blend were varied. Ciprofloxacin hydrochloride was used as a model drug for in-vitro studies. The swelling property of the dry beads is found to be in the range of 80% to 125% from its original dimension. The amount of drug released from the beads was measured by UV-Visible spectrometer at λmax of 278. The drug release from the floating beads can be varied from 7% to 67% by varying the ratios of composition of the blend and pore forming agents to the polymer blend.  From the results it is proved that this system can be used as an oral delivery system with an ability of controlled release of drug in a sustained manner.


[1] Pereira1 A.G.B., Paulino A.T., Rubira1 A.F., Muniz E.C., PEO/Cationic Starch and PEO/Hydrophobic Starch Blends, eXPRESS Polymer Letters, 4(8): 488-499 (2010).
[2] Gopalakrishnan, Chenthilnathan, Floating Drug Delivery System:A Review, Journal of Pharmaceutical Science and Technology, 3(2): 548-554 (2011).
[3]  Anamika Roy, Bajpai J., Bajpai A.K., Dynamics of Controlled Release of Chlorpyrifos from Swelling and Eroding Biopolymeric Microspheres of Calcium Alginate and Starch, Carbohydrate Polymers, 76: 222-231 (2009).
[4] Mayavanshi AV, Gajjar SS, Floating Drug Delivery Systems to Increase Gastric Retention of Drugs: A Review, Research J. Pharm. and Tech. 2011, (4): 345-348 (2008).
[5] Martin J. Blaser., Hypothesis on the Pathogenesis and Natural History of Helicobacter Pylori Induced Inflammation, Gastroenterology, 102: 720-727 (1992).
[6] Balmayor E.R., Barana E.T., Azevedoa H.S., Reis R.L., Injectable Biodegradable Starch/Chitosan Delivery System for the Sustained Release of Gentamicin to Treat Bone Infections, Carbohydrate polymers, 87: 32-39 (2012).
[8] Jung-Ah Han, James N. BeMiller, Preparation and Physical Characteristics of Slowly Digesting ModiWed Food Starches, Carbohydrate Polymers, 67: 366-374 (2007).
[9] Krishna Vamshi Allam, Dr Gannu Praveen Kumar, Vishvasa Cheruku, Anand Jannu, Chaitanya Kumari Bairi. Controlled and Sustained Release Approaches in Developing Suitable Dosage Forms for the Antiretroviral Drug Lamivudine,International Journal of Pharmaceutical Sciences Review and Research, 8(1), (2011).
[10] Ling Chen, Xiaoxi Li, Lin Li, Siyuan Guo. Acetylated Starch-Based Biodegradable Materials with Potential Biomedical Applications as Drug Delivery Systems, Current Applied Physics, 7S1: 90-93 (2007).
[11] Mustafa Yavuz, Tahir Tilki et al.  Electrorheological Behavior of Biodegradable Modified Corn Starch/Corn Oil Suspensions, Carbohydrate Polymers, 79: 318-324 (2010).
[12] Pramod Patil, Someshwara Rao B., Suresh V., Kulkarni, Basavaraj, Chetan Surpur, Anand Ammanage, Formlation and invitro evaluation of floating matrix tablets of  Ofloxacin, Asian J. Res. Pharm. Sci., 1(1): 17-22 (2011).
[13] Qun Wang, Na Zhang , Xianwen Hu , Jianhong Yang , Yumin Du. Alginate/Starch blend fibers and their properties for controlled release. Carbohydrate Polymers, 82: 842-847 (2010).
[14] Satit Puttipipatkhachor, Thaned Pongjanyaku, Aroonsri Priprem. Molecular Interaction in Alginate Beads Reinforced with Sodium Starch Glycolate or Magnesium Aluminum Silicate, and Their Physical Characteristics, International Journal of Pharmaceutics, 293: 51-62 (2005).
[15] Viba Krishnan,S.Sasikumar,Febin prabhu dass, R.vijayaragavan. Effect of Pore Forming Agents on the Physical Characteristics and Release Kinetics of Levofloxacin Hemihydrate from Floating Alginate Drug Delivery System-An in Vitro Study,Trends Biomater. Artif., 24(3): 139-145 (2010).  
[16] Wayne R. Gombotz, Siow Fong Wee. Protein Release from Alginate Matrices, Advanced Drug Delivery Reviews, 31: 267-285 (1998).