Synthesis of N, N΄3, 4-Dialkylamino-1, 2, 5-Oxadiazoles

Document Type : Research Article

Authors

1 Department of Chemistry, Faculty of Science, University of Lorestan, Khorramabad, Lorestan. I.R. IRAN

2 Department of Biology, Faculty of Science, University of Tarbiat Modares, Tehran. I.R. IRAN

Abstract

N, N΄-3, 4-di(methylamino)-1, 2, 5-oxadiazole (1f) was prepared by dehydration of N, N΄-3, 4-di(methylamino)glyoxime (2f) in aqueous potassium hydroxid at 170-180 ˚C. Under similar conditions N, N΄-3, 4-di(benzylamino)-1, 2, 5-oxadiazole (1c) and N, N΄-3, 4-di(isopropylamino)-1, 2, 5-oxadiazole (1e) were not obtained, but, N, N΄-3, 4-di(ethylamino)-1, 2, 5-oxadiazole (1g) was appeared with small amount. 

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References

[1] Willer, R. L., Moore, D. W., J. Org. Chem. 50, 5123(1985).
[2] Gunaekaran, A., Jayachandran, T., Boyer, J. H., Trudell, M. L., J. Heterocyclic. Chem. 32, 1405(1995).
[3] Gunaekaran, A., Trudell, M. L., Boyer, J. H., J. Heterocyclic. Chem. 516, 441(1994).
[4] Gunaekaran, A., Boyer, J. H., Trudell, M. L., J. Heteroatom. Chem. 4, 52(1993).
[5] Chi, M., Gleasan, B., Hill, J., Willer, R. L., U. S. Patent. 5071495. 1991.
[6] Stoner, C. E., Haggerty, B. S., Rheingold, R. L., Brill, T. B., Propellant. Explosive. Pyrotechnics. 7, 82(1992).
[7] Stoner, C. E., Rheingold, R. L., Brill, T. B., Inorg. Chem. 30, 340(1991).
[8] Coburn, M. D., J. Heterocyclic. Chem. 5, 83(1968).
[9] Komin, A. P., Street, R. W., Carmack, M., J. Org. Chem. 40, 2749(1975).
[10] Kakanejadifard, A., Farnia, M., Najafi, G, R., Submitted.
[11] Fischer, J. W., Nissan, R. A., Lowe-Ma, C. K., J. Heterocyclic. Chem. 28, 1677(1991).
[12] Ungnade, H. E and Kinssinger, L., W. Tetrahedron. 19, 143(1963).

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