Document Type : Research Article
Authors
1
a) Department of food science and technology, faculty of biological science, north Tehran branch, Islamic Azad university, Tehran, Iran.
2
Department of food science and technology, faculty of biological science, north Tehran branch, Islamic Azad university, Tehran, Iran.
3
b) Department of Food Science and Technology, Faculty of Biological Science, North Tehran Branch, Islamic Azad University, Tehran, Iran & Faculty of Paramedicine, Iran University of Medical Science, Tehran, Iran.
Abstract
In this paper, some nutraceutical properties of Padina algae extract were identified and its nanoliposomes were prepared to achieve a sustained release of bioactive substance. According to GC-MS analysis, butanoic acid was the foremost substance and n-Hexadecanoic acid was the second major chemical constituent in the extract. In addition, there are significant triterpenoids in the algal extract, which could be the possible reason for Acetylcholinesterase inhibitory activity, which is recognized as a potential therapeutic strategy for the treatment of Alzheimer's disease. The fabrication of algal extract-loaded nanoliposomes was optimized based on the variation of the wall-to-core ratio. The influence of lecithin in different ratios to the concentration of Padina algae extract on mean size, polydispersity index, zeta potential, and entrapment efficiency (EE) was evaluated. The results showed that algal extract-loaded nanoliposomes exhibited a small mean size (318±3.05 to 59.95±0.19 nm), narrow size distribution, acceptable EE (15.7±0.92 to 52.8±0.52%) and good antioxidant activity (92 mg/ml). Morphological characteristics of the nanoliposomes using transmission electron microscope reveal uniform particles with a spherical geometry. Moreover, the optimally formulated nanoliposomes show sustainable release of their contents into the simulated gastrointestinal fluids. These results can appear to the prospect of the possible use of this extract in the nano liposomal structure with a therapeutic approach.
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