SYNTHESIS OF FUNCTIONALIZED POLYETHYLENE GLYCOL COATED METALLIC NANOPARTICLES AND ITS ANTIMICROBIALAPPLICATIONS

Articles in Press

Document Type : Research Article

Authors

1 University of Karachi

2 Department of Chemistry, Faculty of Science, University of Karachi, Karachi-Pakistan. 75270

3 Department of Chemistry, Faculty of Science, University of Karachi, Pakistan.

4 Associate Professor, Department of Biochemistry, Head of Department Medical Lab Technology/Multi Disciplinary Research Laboratory, Quality Assurance Manager, Bahria University Medical and Dental College, Bahria University.

Abstract

The present study emphasizes on the synthesis of novel polyethylene glycol (PEG) coated metaloxide nanoparticles (NPs) and nanocomposite (NCs). The co-precipitation method was adopted for the synthesis of Fe3O4, Fe-Ni, and Fe-Cu in the presence of PEG. The nanoparticles were characterized by scanning electron microscopy (SEM), Fourier Transform Infra-Red (FTIR), and X-Ray Diffraction (XRD) techniques. The FTIR studies proved that PEG with Fe3O4 nanoparticles as well as Fe-Ni and Fe-Cu nanocomposite were bonded together. The average particle sizes of Fe3O4-PEG, Fe-Ni-PEG, and Fe-Cu-PEG nanocomposites were found less than 100nm precisely to be 75.5, 82.8, and 70.2nmrespectively as determine by SEM and XRD analyses. Moreover their functionality for antimicrobial activity against pathogenic microbes including P.aeruginose, Proteus miribilis, Klebsiellatyphi, Staphylococcus aureus, and Saccharomyces cerevisiaewere examined. The Fe-Cu-PEG and Fe-Ni-PEGNCs have stronger antibacterial activity compared to Fe3O4-PEG. This study would be helpful for the treatment of bacterial and viral diseases.

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Iranian Journal of Chemistry and Chemical Engineering

Articles in Press, Accepted Manuscript
Available Online from 19 July 2023

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