Experimental Study and Modeling of Supercritical Extraction of Nicotine from Tabacco Leaves

Document Type: Research Article


1 Department of Chemical Engineering, Science and Research Branch, Islamic Azad University, Tehran, I.R. IRAN

2 Department of Chemical and Petroleum Engineering, Sharif University of Technology, Tehran, I.R. IRAN

3 Department of Chemistry, Tarbiat Modarres University, Tehran, I.R. IRAN


In this work, the solubility of nicotine extracted from tobacco leaves, found in the north of Iran, in supercritical carbon dioxide has been measured. Also the effects of pressure, temperature, extraction dynamic time, and the organic co-Solvent on the amount of nicotine extracted from tobacco leaves have been investigated. It should be stressed that in order to reduce significantly the number of experiments, the experiments have been specified based on the Taguchi experimental design. The results obtained from the experiments showed that at the specified pressure, temperature, volume of modifier and dynamic time, the maximum amount of nicotine can be extracted. The experimental data collected in this research has been correlated using the Redlich-Kwong (R.K) equation of state. The results showed that the conventional cubic R.K equation of state can accurately correlate the experimental solubility data with good accuracy.  


Main Subjects

[1] Pillotti,  A.,  Acta  Physiol.  Scand.Suppl.,  47,  13 (1980).
[2] Pankow, J.F., Mader , B.T., Isabelle , L. M., Andrea Pavlic, W. L. and Ling, C., Environ. Sci. Technol., 31, 2428 (1997).
[3] Okamoto, M., Kita, T., Okuda, H., Tanakan, T. and Nakashima, T., Pharmacol .Toxicol.,75(1), 1 (1994).
[4] Kim, I., Darwin, W. D. and Huestis, M. A., J. Chromatography B., 814 (2), 233 (2005).
[5] Meger, M., Merger-Kossien, I., Schuler-Metz, A. Janket, D. and Scherer, G., Journal of Chromatography B., 778 (1-2), 251 (2002).
[6] Nin Man, Che, et al., Journal of Chromatography B, doi:10.1016/j.j chrom. b.2006.07.026 (2006).
[7] Shepard, H.H., “The Chemistry and Action of Insecticides”, Mc Graw Hill:New York,NY, (1951).
[8] Wanger, F.F. and Comins, D.L., Tetrahedron, 63, 8065 (2007).
[9] Mauin, R.F., Burns, D.J., Keller , I.K., Koehn , K.K., Johnson, M.J. and Gary, S.L., Chem. Educator, 4, 183 (1999).
[10] Hawthornes, S. B., Miller, D. J., Burford, M. D., Langenfeld, J. J., Eckert-Tilotta and  S. Louie, P. K., J. Chromatogr. Sci., 642, p. 301 (1993).
[11] Pawliszyn, J., J. Chromatogr. Sci., 31, p. 31 (1993).
[12] Fischer, M.  and  Jefferies,  T. M.,  J. Agric. Food Chem., 44, p. 1258 (1996).
[13] Rincon, J.  and  De Lucas, A.,  Garcia,  M. A. and Aluarez, A. and Carnicer, A., Sep. Sci. and Tech., 33 (3), p. 411 (1998).
[14] Stahl, E., Qurini, K. W. and Gerard, D., “Dense Gases for Extraction and Refining”,Springer-Verlag, Berlin, (1987).
[15] Narasimha, C.V. and Chakraborty, M.K., Res. Ind., 37, 115 (1992).
[16] Saunders, J. A.,  Blume, D. E.,  J. Chromatogr., 205, p. 147 (1981).
[17] Severson, R. F., Mc Duffine, K. L., Arrendale, R. F., Gwynn, G. R., Chaplin, J. F., Johnson, A. W., J. Chromatogr., 211, p. 111 (1981).
[18] Sudan, B. J. L., Brouillard, C., Strehler, C. Strub, H., Sterboul, J., Stain-Laudy, J., J. Chromatogr., 288,
p. 415 (1984).
[19] Hawthorne, S. B., Anal. Chem., 62, 633A (1990).
[20] Reinoso, B. D., Moure, A., Dominguez, H. and Parajd, J.C., J. Agric. Food  Chem., p. 2441 (2006).
[21] Hubert, P. and Vitzthum, O. G., Angew. Chem. Int. Ed. Engl., 17, p. 710 (1978).
[22] Roselius, W., Vitzthum, O., Hubert, P.,U. S.Patent 4,153,063, (1979).
[23] Sharma, A. K., Prokopczyk, B. and Hoffman, D., J. Agric. Food Chem., 39, p. 508 (1991).
[24] van der Waals, J.D., Ph. D. Thesis, Lei den, The Netherlands, (1873).
[25] Redlich, O., Kwong, J.N.S., Chem. Rev., 44, 233 (1949).
[26] Sova, G., Chem. Eng. Sci., 27, 1197 (1972).
[27] Peng, D.Y.,  Robinson, D. B.,  Ind.  Eng.  Chem. Fundam., 15, p. 59 (1976).
[28] Mc Quarrie, D.A., "Statistical Mechanics",Hatper&Row,New York, (1976).