The Effect of Process Variables on the Properties of Ketoprofen Loaded Solid Lipid Nanoparticles of Beeswax and Carnauba Wax

Document Type : Research Article

Authors

1 Faculty of Chemical Engineering, Tarbiat Modares University, Tehran, I.R. IRAN

2 Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences,Tehran, I.R. IRAN

Abstract

Solid Lipid Nanoparticles (SLNs) have emerged as an alternative colloidal carriers for sustained release of lipophilic drugs with poor absorption and water solubility. This manuscript describes the effect of process variables on the production of Solid Lipid Nanoparticles (SLNs) from beeswax and carnauba wax and ketoprofen release from these carriers. It was found that by increasing drug content from 0.5 to 1.5% w/v the average particle size of SLNs increased from 82 to 116 nm and drug loading increased from 10.7 to 26.6% while entrapment efficiency remained almost constant (≈ 97%). Unexpectedly, the average size of SLNs increased from 82 to 150 nm by increasing homogenization time from 5 to 15 min. Increasing homogenization intensity from 11000 to 24000 rpm resulted in the particle size decrease from 108 to 82 nm. The rate of drug release from nanparticles loaded with 0.5% w/v ketoprofen increased with increasing the ionic concentration of phosphate buffer solution from 0.05 to 0.1 M.

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References

[1] You J., Wan F., Cui F.D., Sun Y., Du Y.-Z., Hu, F.Q., Preparation and Characteristics of Vinorelbine Bitartrate-Loaded Solid Lipid Nanoparticles, Int. J. Pharm., 343, p. 270 (2007).
[2] Shah K.A., Date A.A., Joshi M.D., Patravale V.B., Solid Lipid Nanoparticles (SLN) of Tretinoin: Potential in Topical Delivery, Int. J. Pharm., 345, p. 163 (2007).
[3] Hou D., Xie C., Huang K., Zhu C., The Production and Characteristics of Solid Lipid Nanoparticles (SLNs), Biomaterials, 24, p. 1781 (2003).
[4] Mehnert W., Mader K., Solid Lipid Nanoparticles Production, Characterization and Applications, Adv. Drug deliv. Rev., 47, p. 165 (2001).
[5] Byung-Do K., Na K., Choi H.-K., Preparation and Characterization of Solid Lipid Nanoparticles (SLN) Made of Cacao Butter and Curdlan, Eur. J. Pharm Sci., 24, p. 199 (2005).
[6] Meastrelli F., Gonzalez-Rodriguez M.L., Rabasco A.M., Mura P., Effect of Preparation Technique on the Propertise of Liposomes Encapsulating Ketoprofen-Cyclodextrin Complexes Aimed for Transdermal Delivery, Int. J. Pharm., 312, p. 53 (2006).
[7] Paolino D., VenturaC.A., Nistico S., Puglisi G., Fresta M., Lecithin Microemulsions for the Topical Administration of Ketoprofen: Percutaneous Adsorbtion Through Human Skin and in Vivo Human Skin Tolerability, Int. J. Pharm., 244, p. 21 (2002).
[8] Vergote G.J., Vervate C., Van Driessche I., Hoste S., De Smedt S., Demeester J., Jain R.A., Ruddy, S., Remon J.P., An Oral Controlled Release Matrix Pellet Formulation Containing Nanocrystalline Ketoprofen, Int. J. Pharm., 219, p. 81 (2001).
[9] Ahlin P., Optimization of Procedure Parameters and Physical Stability of Solid Lipid Nanoparticles in Dispersions, Acta Pharm., 48, p. 257 (1998).
[10] Gasco M.R., Method for Producing Solid Lipid Microspheres Having Narrow Size Distribution, US Patent, 5,250,236 (1993).
[11] Valenta C., Wanka M., Heidlas J., Evaluation of Novel Soya-Lecithin Formulations for Dermal Use Containing Ketoprofen as a Model Drug, J. Controlled Release, 63, p. 165 (1999).
[12] Maa Y.F., Hsu C., Liquid-Liquid Emulsification by Rotor-Stator Homogenization, J. Controlled Release, 38, p. 219 (1996).
[13] Liu J., Gong T., Wang C., Zhong Z., Zhang Z.-R., Solid Lipid Nanoparticles Loaded with Insulin by Sodium Cholate-Phosphatidylcholine Based Mixed Micelles: Preparation and Characterization, Int.
J. Pharm., 340, p. 153 (2007).
[14] Bunjes H., Characterization of Solid Lipid Nano and Microparticles, In: Nastruzzi, C., "Liposhpheres in drug targets and delivery", CRC Press,New York, 41 (2005).
[15] Cavalli R., Peiraa E., Caputo O., Gasco M.R., Solid Lipid Nanoparticles as a Carriers of Hydrocortisone and Progestrone Complexes with B-Cyclodextrins, Int. J. Pharm., 182, p. 59 (1999).
[16] Lv Q., Yu A., Xi Y., Li H., Song Z., Cui J., Cao F., Zhai G., Development and Evaluation of Penciclovir-Loaded Solid Lipid Nanoparticles for Topical Delivery, Int. J. Pharm., 372, p. 191 (2009).
[17] Westsen K., Siekmann B., Koch M.H.J., Investigation on the Physical State of Lipid Nanoparticles by Synchrotron Radiation X-ray Diffraction, Int. J. Pharm., 93, p. 189 (1993).
[18] Hurrell S., Cameron R.E., The Effect of Buffer Concentration, pH and Buffer Ions on the Degradiation and Drug Release from Polyglycolide, Polym. Int., 52, p. 358 (2003).
Iranian Journal of Chemistry and Chemical Engineering
Volume 29, Issue 4 - Serial Number 56
December 2010
Pages 181-187

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