An Efficient Protocol for the Synthesis of Carboacyclic Nucleosides via Aza-Conjugate Addition Reaction

Document Type: Research Article

Authors

1 Faculty of Chemistry, Bu-Ali Sina University, Hamedan, I.R. IRAN

2 Department of Chemistry, Payame Noor University (PNU), Tehran, I.R. IRAN

3 Department of Chemistry, Faculty of Sciences, Persian Gulf University, Bushehr, I.R. IRAN

Abstract

A new efficient method for the synthesis of carboacyclic nucleosides as biologically interesting compounds via aza-conjugate addition of pyrimidine nucleobases to a,β-unsaturated esters in the presence of catalytic amount of LiOH.H2O (1.2-4.8 mol%) under microwave irradiation is described. This method affords the title compounds in good to excellent yields and in short reaction times.

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