Synthesis of Poly-Substituted Quinolines via Friedländer Hetero-Annulation Reaction Using Silica-Supported P2O5 under Solvent-Free Conditions

Document Type: Research Article


1 Department of Chemistry, Faculty of Sciences, Persian Gulf University, Bushehr, I.R. IRAN

2 Department of Chemistry, Payame Noor University (PNU), Tehran, I.R. IRAN

3 Faculty of Chemistry, Bu-Ali Sina University, Hamedan, I.R. IRAN


A highly efficient, simple and green solvent-free protocol for the preparation of poly-substituted quinolines via Friedländer hetero-annulation reaction between 2-aminoaryl ketones and carbonyl compounds in the presence of silica-supported P2O5 (P2O5 / SiO2) is described. In this method, the title compounds are obtained in high to excellent yields and in short reaction times.  


Main Subjects

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