Efficient Synthesis and Deprotection of Semicarbazones under Solvent-Free Conditions

Document Type: Research Article


1 Department of Chemistry, Iran University of Science and Technology, P.O. Box 16846-13114 Tehran, I.R. IRAN

2 Islamic Azad University, East Tehran Branch, Tehran, I.R. IRAN


Effective methodologies for efficient preparation of semicarbazones from aldehydes or ketones via milling and the subsequent regeneration of the parent carbonyls by gaseous nitrogen dioxide are described under solid-solid and gas-solid reaction conditions, respectively. These methods are fast, simple and environmentally benign which do not require the use of any auxiliaries such as catalysts or solid supports in their procedures.


Main Subjects

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