Voltammetric simultaneous determination of ascorbic acid and acetaminophen based on graphite screen printed electrode modified with a La3+-doped ZnO nanoflowers

Document Type: Research Article


1 Department of Chemistry, Kerman Branch, Islamic Azad University, Kerman, Iran

2 Environment Department, International Center for Science, High Technology & Environmental Sciences, Kerman, Iran

3 NanoBioElectrochemistry Research Center, Bam University of Medical Sciences, Bam, Iran


In this work, an easy method was employed to successfully develop La3+-doped ZnO nanoflowers and guar-gum (GG) modified screen printed electrode (La3+/ZnO/GG/SPE), and La3+/ZnO/GG/SPE was applied for the electrochemically detection of ascorbic acid (AA). The electrochemical methods, such as cyclic voltammetry (CV), chronoamperometry (CHA) and differential pulse voltammetry (DPV) were used to evaluate the electrochemical performances toward ascorbic acid on the La3+/ZnO/GG/SPE. Good linearship was observed for ascorbic acid in the ranges of 1.0–700.0 µM, with the detection limits of 0.03 µM. Moreover, this sensor proved favorable to simultaneously determine ascorbic acid and acetaminophen. Finally, the modified electrode has fairly good performance during the employment of real sample analysis to determine the content of ascorbic acid. These results indicate that the La3+-doped ZnO nanoflowers are supposed to be a promising material in the electrochemical determination of ascorbic acid and acetaminophen in real samples.


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