Sulfonated magnetic nanoparticles as recyclable catalyst for facile one-pot green synthesis of 3,4-dihydro-2H-indazolo[1,2-b]phthalazine-1,6,11(13H)-trione derivatives

Document Type: Research Article

Authors

1 Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

2 Department of Chemistry, Bu-Ali Sina University, Zip Code 65178, Hamedan, Iran

3 Department of Chemistry, Bu-Ali Sina University, Hamedan 5178, Iran

4 Department of Chemistry, Bu-Ali Sina University, Zip Code 65178, Hamedan, Iran.

Abstract

Sulfonated magnetic nanoparticles (SO3H-Fe3O4@SiO2 MNPs) have been explored as an efficient, cost effective, and recyclable nanocatalyst for the facile synthesis of 3,4-dihydro-2H-indazolo[1,2-b]phthalazin-1,6,11(13H)-triones through one-pot three-component reaction between aldehydes, dimedone and phthalhydrazide under mild and green (solvent-free) conditions. Simple separation of catalyst using an external magnet, efficient recyclability of the developed magnetic nanocatalyst up to five fresh runs without significant loss in its catalytic activity, excellent yields of the designed reactions (88 to 98%), low reaction times as well as solvent-free and facial reaction condition are some advantages of the present procedure that qualified the fabricated magnetic nanocatalyst for industrial applications.

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