Synthesis, Reactions and Antioxidant activity of 5-(3', 4'-dihydroxy-tetrahydrofuran-2'-yl)-2-methyl-3-carbohydrazide

Document Type: Research Article

Authors

1 Department of chemistry faculty of science Alexandria university

2 Chemistry Department, Faculty of Science, Alexandria University, Alexandria 21231, Egypt;

3 Biochemistry Department, Faculty of Science, Alexandria University, Alexandria

Abstract

Abstract: In this manuscript, we describe the synthesis of the carbohydrazide 2. Acid catalyzed condensation with a number of carbonyl compounds to afford the corresponding carbohydrazide derivatives 3-12. Their acetylation afforded the corresponding acetyl derivatives 13-22. Oxidative cyclization of O-acetyl derivatives 19-22 afforded the corresponding 1,3,4-oxadiazole derivatives 23-26. On the other hand, condensation of the dicarbonyl compound 27 with a number of aroylhydrazines to give the corresponding bisaroylhydrazones 28-32 cyclization of 28-31 afforded 1,3,4-oxadiazoles 33-36.The structures of the prepared compounds were confirmed by 1HNMR and Mass Spectra.The mechanism of formation of the products were discussed. Furthermore, antioxidant activities of some of the prepared compounds were examined

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