Nano-ceria (CeO2): An efficient catalyst for the multi-component synthesis of a variety of key medicinal heterocyclic compounds

Document Type: Review Article

Authors

1 Department of Chemistry, Payame Noor University, Tehran, Iran

2 Department of Engineering Science, College of Engineering, University of Tehran, P.O. Box 11365-4563, Tehran, Iran

3 Department of Chemistry, Payame Noor University, 19395-4697 Tehran, Iran

Abstract

Organic chemistry covers more than 12.5 million known carbon-containing compounds, about half of them contain heterocyclic systems. In particular, heterocycles are common structural units of the vast majority of marketed drugs . Of the top five small molecule drugs by US retail sales in 2014, four are contained at least one heterocyclic fragment in their structures. Due to the diversity of this class of organic compounds in the therapeutic response profile, many researchers have been working to develop novel, practical and convenient protocols for their synthesis to improve energy consumption, atom economy and reaction yields.
This review gives an overview of the applications of ceria nanoparticles as inexpensive, efficient, reusable, and environmentally sustainable heterogeneous catalyst for the synthesis of a variety of key medicinal heterocyclic compounds. Literature has been surveyed from 2005 to 2018.

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