Ionic liquid an efficient solvent and catalyst for synthesis of 1-aminoalkyl-2-naphthol and naphthoxazine derivatives

Document Type: Research Article


Islamic Azad University, Qaemshahr Branch


The aim of doing this research is a one-pot three-component synthesis of 1-aminoalkyl-2- naphthol and naphthoxazine derivatives using the condensation of β-naphthol with various aldehydes and amines in the presence of ionic liquid {[(secondary butyl) methyl] imidazolium bromide} {[sec-bmim]+ Br-, as an efficient catalyst and solvent. The catalyst was prepared according to a previously published literature procedure using 1-methyl imidazole and 2-bromobutane. Furthermore, the catalyst could be recovered conveniently and reused. This protocol has proved to be efficient in terms of good to excellent yields, lower reaction times, mild reaction conditions, eco-friendly methodology, clean reaction profiles, and a simple work‐up procedure. The reactions carried out in 25˚C and mild reaction conditions without any need to high temperature.


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