Ionic Liquid an Efficient Solvent and Catalyst for Synthesis of 1-aminoalkyl-2-naphthol and Naphthoxazine Derivatives

Document Type: Research Article


Department of Chemistry, Qaemshahr Branch, Islamic Azad University, Qaemshahr, I.R. IRAN


The aim of doing this research is a one-pot three-component synthesis of 1-aminoalkyl-2- naphthol and naphthoxazine derivatives using the condensation of β-naphthol with various aldehydes and amines in the presence of ionic liquid {[(secondary butyl) methyl] imidazolium bromide} {[sec-bmim]+ Br-, as an efficient catalyst and solvent. The catalyst was prepared according to a previously published literature procedure using 1-methyl imidazole and 2-bromo butane. Furthermore, the catalyst could be recovered conveniently and reused. This protocol has proved to be efficient in terms of good to excellent yields, lower reaction times, mild reaction conditions, eco-friendly methodology, clean reaction profiles, and a simple workup procedure. The reactions carried out in 25˚C and mild reaction conditions without any need to high temperature.


Main Subjects

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