Tavakolyan pour, F., Waqifhusain, S., Rastegar, H., Saber Tehrani, M., Abroomand Azar, P. (2017). Electrochemical oxidation of flavonoids and interaction with DNA on the surface of supramolecular ionic liquid grafted on graphene modified glassy carbon electrode. Iranian Journal of Chemistry and Chemical Engineering (IJCCE), (), -.
Fahimeh Tavakolyan pour; Syed Waqifhusain; Hossein Rastegar; Mohammad Saber Tehrani; parviz Abroomand Azar. "Electrochemical oxidation of flavonoids and interaction with DNA on the surface of supramolecular ionic liquid grafted on graphene modified glassy carbon electrode". Iranian Journal of Chemistry and Chemical Engineering (IJCCE), , , 2017, -.
Tavakolyan pour, F., Waqifhusain, S., Rastegar, H., Saber Tehrani, M., Abroomand Azar, P. (2017). 'Electrochemical oxidation of flavonoids and interaction with DNA on the surface of supramolecular ionic liquid grafted on graphene modified glassy carbon electrode', Iranian Journal of Chemistry and Chemical Engineering (IJCCE), (), pp. -.
Tavakolyan pour, F., Waqifhusain, S., Rastegar, H., Saber Tehrani, M., Abroomand Azar, P. Electrochemical oxidation of flavonoids and interaction with DNA on the surface of supramolecular ionic liquid grafted on graphene modified glassy carbon electrode. Iranian Journal of Chemistry and Chemical Engineering (IJCCE), 2017; (): -.
Electrochemical oxidation of flavonoids and interaction with DNA on the surface of supramolecular ionic liquid grafted on graphene modified glassy carbon electrode
Articles in Press, Accepted Manuscript , Available Online from 20 December 2017
1Department of Chemistry, Islamic Azad university science and Research Branch, Tehran, Iran
2Food and Drug Control Reference Labratories, 408 valiasr street. Tehran, Iran
Abstract
ABSTARCT: The study of the interaction between DNA and small molecules such as drugs is one of the current general interest and importance. In this paper, the electrochemical investigation of the interaction between some flavonoids such as rutin, quercetin, and hesperidin with dsDNA on the surface of supramolecular ionic liquid grafted on the graphene oxide modified glassy carbon electrode (SIL-GO/GCE) is reported for the first time. The apparent binding constant (K) of the interaction between flavonoids and dsDNA was calculated using the current titrations. The apparent binding constants (K) of rutin, quercetin and hesperidin were calculated to be 4.3×105, 2.1×105 and 9.2×1-6 M-1, respectively. Furthermore, the electrochemical behavior of rutin on the surface of SIL-GO/GCE was studied in details using cyclic voltammetry and linear sweep voltammetry. The mechanism of electrochemical redox reaction of rutin was proposed. When DNA was added into flavonoid solutions, their cathodic peak currents were decreased with few changes in the peak potentials. Furthermore, the interaction between rutin and bovine serum albumin was studied using differential pulse voltammetry. In conclusion, the SIL-GO/GCE provides a promising platform for the study of interaction between DNA and small molecules.
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