Platinum-based anticancer drugs are chemotherapeutic agents to treat cancer. Carboplatin (cis diammine cyclobutane dicarboxylate platinum (II)) is a second generation drug that has less toxic than cisplatin, allowing for high dosages. In the first stage, 1,3-Cyclobutane dicarboxylic acid, a key intermediate for the preparation of carboplatin, have been synthesized in good yields using different methodology to achieve high purity then carboplatin was synthesized from the reaction of the prepared ligand with cisplatin. Purity of prepared carboplatin was confirmed by High-Performance Liquid Chromatography (HPLC). Platinum(II) complex carboplatin,have been characterized with 1H and 13C nuclear magnetic resonance spectra and infrared spectroscopy.
Nemati kharat, A., Tamaddoni Jahromi, B., Mohammadifar, E., & Zareyi, J. (2017). Synthesis of Cis-Diammine (1,1-cyclobutane dicarboxylate) Platinum(II). Iranian Journal of Chemistry and Chemical Engineering, 36(4), 39-43. doi: 10.30492/ijcce.2017.28707
MLA
Ali Nemati kharat; Bahareh Tamaddoni Jahromi; Ehsan Mohammadifar; Jaleh Zareyi. "Synthesis of Cis-Diammine (1,1-cyclobutane dicarboxylate) Platinum(II)". Iranian Journal of Chemistry and Chemical Engineering, 36, 4, 2017, 39-43. doi: 10.30492/ijcce.2017.28707
HARVARD
Nemati kharat, A., Tamaddoni Jahromi, B., Mohammadifar, E., Zareyi, J. (2017). 'Synthesis of Cis-Diammine (1,1-cyclobutane dicarboxylate) Platinum(II)', Iranian Journal of Chemistry and Chemical Engineering, 36(4), pp. 39-43. doi: 10.30492/ijcce.2017.28707
VANCOUVER
Nemati kharat, A., Tamaddoni Jahromi, B., Mohammadifar, E., Zareyi, J. Synthesis of Cis-Diammine (1,1-cyclobutane dicarboxylate) Platinum(II). Iranian Journal of Chemistry and Chemical Engineering, 2017; 36(4): 39-43. doi: 10.30492/ijcce.2017.28707