Photochemical Degradation of Fluocinolone Acetonidin Drug in Aqueous Solutions Using Nanophotocatalyst ZnO Doped by C, N, and S

Document Type: Research Article


1 Department of Pharmaceutical Science, North Tehran Branch, Islamic Azad University, Tehran, I.R. IRAN

2 Department of Chemistry, Faculty of Science, Lahijan Branch, Islamic Azad University, Lahijan, I.R. IRAN


It has been shown that the photocatalytic activity of doped semiconductor with some nonmetals is higher than a pure semiconductor. Hence, with an attempt to achieve higher photocatalytic activity, doped ZnO with C, N, and S was prepared by a sedimentary process and used for the photocatalytic degradation of Fluocinolone Acetonidin as a drug in aqueous solutions.  X-Ray Diffraction (XRD), Energy Dispersion X-ray (EDX), X-ray Photoelectron Spectroscopy (XPS) and Scanning Electron Microscopy (SEM) were used to characterize the microstructure and morphology of the precursor and the products. The photocatalytic degradation of the drug was investigated using supported ZnO/C, N, and S photocatalyst under UV light irradiation. We also studied the influence of the basic photocatalytic parameters as well as irradiation time, the initial concentration of the drug, pH of the solution, amount of nanoparticles and addition of oxidant on the reaction. The optimum conditions of degradation were obtained accordingly: concentration of Fluocinolone Acetonidin,  20 ppm; the amount of photocatalyst, 7 mg; oxidant (K2S2O8), 5 mM; irradiation time, 6 h in  pH=9. Kinetic analysis demonstrated that the amount of Fluocinolone Acetonidin photocatalytic degradation can be fitted by a pseudo-first-order model.


Main Subjects

[1] Emad S., Chaudhuri M., Degradation of Amoxicillin, Ampicillin and Cloxacillin Antibiotics in Aqueous Solution by the UV/Zno Photocatalytic Process, Journal of Hazardous Materials, 173: 445-449 (2010). 

[2] Ikehata K., Jodeiri Naghashkar N., Gamal El-Din M., Degradation of Aqueous Pharmaceuticals by Ozonation and Advanced Oxidation Processes: A Review, Ozone: Science & Engineering Journal, 28(6): 353–414 (2006).

[6] Thou-Jen W., Mu-Tao H.,  Huang-Han C., Visible-Light Photocatalytic Degradation of Methylene Blue with Laser-Induced Ag/ZnO Nanoparticles, Applied Surface Science, 258(7): 2796-2801 (2012).

[7] Giahi M., Taghavi H., Habibi S., Photocatalytic Degradation of Betamethasone Sodium Phosphate in Aqueous Solution using ZnO Nanopowder, Russian Journal of Physical Chemistry A, 86(13): 2003-2007 (2012).

[8] Giahi M., Badalpoor N., Habibi S., Taghavi H., Synthesis of CuO/ ZnO Nanoparticles and Their Application for Photocatalytic Degradation of Lidocaine HCl by the Trial-and-error and Taguchi Methods, Bulletin of the Korean Chemical Society, 34(7): 2176-2182 (2013).

[9] Shifu C., Zhao W., Zhang S., Liu W., Preparation, Characterization and Photocatalytic Activity of N-Containing ZnO Powder, Chemical Engineering Journal, 148: 263-269 (2009).

[10] Li, Z.; Suyuan, S.; Xiao, X.; Bin, Z.; Alan, M., Photocatalytic Activity and DFT Calculations on Electronic Structure of N-Doped ZnO/Ag Nanocomposites, Catalysis Communications,12(10): 890-894 (2011).

[11] Mapa M., Gopinath C.S., Combustion Synthesis of Triangular and Multifunctional ZnO1−xNx (x ≤ 0.15) Materials, Chemistry of Materials, 21(2): 351-359 (2009).

[12] Chen L.C., Tu Y.J., Wang Y.S., Kan R.S., Huang C.M., Characterization and Photoreactivity of N-, S-, and C-Doped ZnO under UV And Visible Light Illumination, Journal Of Photochemistry And Photobiology A: Chemistry, 199: 170–178 (2008).

[13] Haque M. M., Muneer M., Photodegradation of Norfloxacin in Aqueous Suspensions of Titanium Dioxide, Journal of Hazardous Materials, 145: 51-57 (2007).

[14] Giahi M., Taghavi H., Saadat S., Abdolahzadeh Ziabar A., Synthesis of CuO-ZnO and Its Application in Photocatalytic Degradation of Nonylphenol Polyethoxylate, Optoelectronics and advanced materials - rapid communications, 9: 1514-1519 (2015).    

[16] Giahi M., Habibi S., Toutounchi S., Khavei M.,  Photocatalytic Degradation of Anionic Surfactant Using Zinc Oxide Nanoparticles, Russian Journal of Physical Chemistry A, 86(4): 689–693(2012).

[17] Height M., Pratsinis S., Mekasuwandumrong O., Praserthdam P., Ag-ZnO Catalysts for UV-Photodegradation of Methylene Blue, Applied Catalysis B: Environmental, 63: 305-312 (2006).

[18] Daneshvar, N., Salari, D., Khataee, A. R., Photocatalytic Degradation of Azo Dye Acid Red 14 in Water on ZnO as an Alternative Catalyst to TiO2, Journal of Photochemistry and Photobiology A: Chemistry, 162: 317-322 (2004).

[19] Rauf M.A., Salman Ashraf S., Fundamental Principles and Application of Heterogeneous Photocatalytic Degradation of Dyes in Solution, Chemical Engineering Journal, 151: 10–18 (2009).

[20] Giahi M., Moradidoost A., Taghavi H., Bagherinia M. A.,  The Photocatalytic Degradation of Cationic Surfactant (CPC) from Wastewater in the Presence of Nano-Zno Using Taguchi Method, Russian Journal of Physical Chemistry A, 87(13): 2279–2284 (2013).