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Nakhaei, A., Davoodnia, A., Yadegarian, S. (2018). An Efficient Green Approach for the Synthesis of Fluoroquinolones Using Nano Zirconia Sulfuric Acid as Highly Efficient Recyclable Catalyst in two Forms of Water. Iranian Journal of Chemistry and Chemical Engineering (IJCCE), 37(3), 33-42.
Ahmad Nakhaei; Abolghasem Davoodnia; Sepideh Yadegarian. "An Efficient Green Approach for the Synthesis of Fluoroquinolones Using Nano Zirconia Sulfuric Acid as Highly Efficient Recyclable Catalyst in two Forms of Water". Iranian Journal of Chemistry and Chemical Engineering (IJCCE), 37, 3, 2018, 33-42.
Nakhaei, A., Davoodnia, A., Yadegarian, S. (2018). 'An Efficient Green Approach for the Synthesis of Fluoroquinolones Using Nano Zirconia Sulfuric Acid as Highly Efficient Recyclable Catalyst in two Forms of Water', Iranian Journal of Chemistry and Chemical Engineering (IJCCE), 37(3), pp. 33-42.
Nakhaei, A., Davoodnia, A., Yadegarian, S. An Efficient Green Approach for the Synthesis of Fluoroquinolones Using Nano Zirconia Sulfuric Acid as Highly Efficient Recyclable Catalyst in two Forms of Water. Iranian Journal of Chemistry and Chemical Engineering (IJCCE), 2018; 37(3): 33-42.

An Efficient Green Approach for the Synthesis of Fluoroquinolones Using Nano Zirconia Sulfuric Acid as Highly Efficient Recyclable Catalyst in two Forms of Water

Article 4, Volume 37, Issue 3 - Serial Number 89, May and June 2018, Page 33-42  XML PDF (567.7 K)
Document Type: Research Article
Authors
Ahmad Nakhaei email 1; Abolghasem Davoodniaorcid 2; Sepideh Yadegarian1
1Young Researchers and Elite Club, Mashhad Branch, Islamic Azad University, Mashhad, I.R. IRAN
2Department of Chemistry, Mashhad Branch, Islamic Azad University, Mashhad, I.R. IRAN
Abstract
Various antibacterial fluoroquinolone compounds were prepared by the direct amination of 7-halo-6- fluoroquinolone-3-carboxylic acids with a variety of piperazine derivatives and (4aR,7aR)-octahydro-1H-pyrrolo[3,4-b] pyridine using Zirconia Sulfuric Acid (ZrSA) nanoparticle, as a catalyst in the presence of ordinary or magnetized water upon reflux condition. The results showed that ZrSA exhibited high catalytic activity towards the synthesis of fluoroquinolone derivatives in two forms of water. However, the magnetized water showed better results. Furthermore, the catalyst was recyclable and could be reused at least three times without any discernible loss in its catalytic activity. Overall, this new catalytic method for the synthesis of fluoroquinolone derivatives provides rapid access to the desired compounds in refluxing water following a simple work‐up procedure and avoids the use of harmful organic solvents. This method, therefore, represents a significant improvement over the methods currently available for the synthesis of fluoroquinolone derivatives.
Keywords
Fluoroquinolone derivatives; Antibacterial; Fast and green synthesis; Zirconia sulfuric acid (ZrSA); Ordinary or magnetized water
Main Subjects
Catalysts, Kinetics, Reactor
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