An Efficient Green Approach for the Synthesis of Structurally Diversified Spirooxindoles Using Sulfonic Acid Functionalized Nanoporous Silica (SBA-Pr-SO3H)
One-pot multicomponent reaction between isatin, barbituric acid, and 6-amino-1,3-dimethyl uracil was investigated in the presence of sulfonic acid functionalized nanoporous silica (SBA-Pr-SO3H) and resulted in the formation of spirooxindole dipyrimidines. Spirooxindole unit is found in many natural products and biologically active molecules and 1,4-dihydropyridines are an important class of compounds with interesting biological activities such as vasolidator, antitumor, antidiabetic, bronchodilator and anti-atherosclerotic activities.Excellent yields and short reaction timesare related to the highefficiency of SBA-Pr-SO3H that the reactions take place easily in its nano-pores. Mild reaction conditions and easy work-up procedures are other advantages of this green method.
Mohammadi Ziarani, G., Aleali, F., Lashgari, N., & Badiei, A. (2016). An Efficient Green Approach for the Synthesis of Structurally Diversified Spirooxindoles Using Sulfonic Acid Functionalized Nanoporous Silica (SBA-Pr-SO3H). Iranian Journal of Chemistry and Chemical Engineering, 35(1), 17-23. doi: 10.30492/ijcce.2016.18802
MLA
Ghodsi Mohammadi Ziarani; Faezeh Aleali; Negar Lashgari; Alireza Badiei. "An Efficient Green Approach for the Synthesis of Structurally Diversified Spirooxindoles Using Sulfonic Acid Functionalized Nanoporous Silica (SBA-Pr-SO3H)". Iranian Journal of Chemistry and Chemical Engineering, 35, 1, 2016, 17-23. doi: 10.30492/ijcce.2016.18802
HARVARD
Mohammadi Ziarani, G., Aleali, F., Lashgari, N., Badiei, A. (2016). 'An Efficient Green Approach for the Synthesis of Structurally Diversified Spirooxindoles Using Sulfonic Acid Functionalized Nanoporous Silica (SBA-Pr-SO3H)', Iranian Journal of Chemistry and Chemical Engineering, 35(1), pp. 17-23. doi: 10.30492/ijcce.2016.18802
VANCOUVER
Mohammadi Ziarani, G., Aleali, F., Lashgari, N., Badiei, A. An Efficient Green Approach for the Synthesis of Structurally Diversified Spirooxindoles Using Sulfonic Acid Functionalized Nanoporous Silica (SBA-Pr-SO3H). Iranian Journal of Chemistry and Chemical Engineering, 2016; 35(1): 17-23. doi: 10.30492/ijcce.2016.18802