Experimental Study of Effective Parameters in Production of Carbamazepine Nanoparticles

Document Type: Research Article


Department of Chemical Engineering, Faculty of Engineering, University of Guilan, Rasht, I.R. IRAN


In this study, confined impinging liquid jets are used to produce nanoparticles of carbamazepine (CBZ). The effect of operating parameters, such as the kind of solvent,CBZ concentration, flow rate of solution and antisolvent on particle size, are experimentally investigated. The Scanning Electron Micrograph (SEM) photomicrographs show that nanodrug with smaller particle is achievable by using solvent with more supersaturation. Meanwhile, decreasing concentration causes the production of smaller particles in the range of 430 to 190nm and by increasing flow rate of solution, the particle size increases from 240 to 340 nm. Furthermore, the physical states of particles are investigated by Differential Scanning Calorimetry (DSC) test.


Main Subjects

[2] Lipinski Ch.A., Drug-Like Properties and the Causes of Poor Solubility and Poor Permeability, Journal of Pharmacological and Toxicological Methods, 44: 235-249 (2000).

[3] Ba-Abbad M.M., Kadhum A.A.H., Mohamad A.B., Takriff M.S., Sopian K., Optimization of Process Parameters using D-Optimal Design for Synthesis of ZnO Nanoparticles via Sol-Gel Technique, Journal of Industrial and Engineering Chemistry, 19(1): 99-105 (2013).

[4] Ali H.S.M., York P., Blagden N., Preparation of Hydrocortisone Nanosuspension Through a Bottom-up Nano Precipitation Technique Using Microfluidic Reactors, International Journal of Pharmaceutics, 375: 107-113 (2009).

[5] Bazdidi-Tehrani F., Imanifar A., Khajehhasani S., Rajabi-Zargarabadi M., Normal-Velocity Relaxation and Higher Order Algebraic Heat Flux Models Applicable to an Axisymmetric Impinging Jet, Journal of Dispersion Science and Technology, 33: 556-564 (2012).

[6] Alaei M., Mahjoub A.R., Rashidi A., Preparation of Different WO3 Nanostructures and Comparison of Their Ability for Congo Red Photo Degradation, Iranian Journal Chemistry and Chemical Engineering (IJCCE), 31: 31-36 (2012).

[7] Chiou H., Chan H.-K., Heng D., Prud’homme R.K., Raper J.A., A Novel Production Method for Inhalable Cyclosporine A Powders by Confined Liquid Impinging jet Precipitation, Journal of Aerosol Science, 39: 500-509 (2008).

[8] SaienJ., Ojaghi S.A., Effect of Aqueous Phase pH on Liquid-Liquid Extraction with Impinging-Jets Contacting Technique, journal of Industrial and Engineering Chemistry , 16:1001-1005 (2010).

[9] Homaunmir V., Tohidi S.H., Grigoryan G., Characterization of Sol-Gel Derived CuO@SiO2 Nano Catalysts towards Gas Phase Reactions, Iranian Journal Chemistry and Chemical Engineering (IJCCE), 32: 37-44 (2013).

[10]  Park M.-W., Yeo S.-D., Antisolvent Crystallization of Carbamazepine from Organic Solutions, Chemical Engineering Research and Design, 90: 2202-2208 (2012).

[11] Patel R.B., Patel M.R., Bhatt K.K., Patel B.G., Formulation Consideration and Characterization of Microemulsion Drug Delivery System for Transnasal Administration of Carbamazepine, Bulletin of Faculty of Pharmacy, Cairo University, 51: 243-253 (2013).

[12] Beck Ch., Dalvi S.V., Dave R.N., Controlled Liquid Antisolvent Precipitation using A Rapid Mixing Device, Chemical Engineering Science, 65: 5669-5675 (2010).

[13] Ali H.M.S., Blagden N., York P., Amani A., Brook T., Artificial Neural Networks Modelling the Prednisolone Nanoprecipitation in Microfluidic Reactors, European Journal of Pharmaceutical Science, 37: 514-522 (2009).

[14] Zhang J.-Y., Shen Z.-G., Zhong J., Hu T.-T., Chen J.-F., Ma Z.-Q., Yun J., Preparation of Amorphous Cefuroxime Axetil Nanoparticles by Nanoprecipitation Method without Surfactants, International Journal of Pharmaceutics, 323: 153-160 (2006).

[15] Ghaffarian H.R., Saiedi M., Sayyadnejad M.A., Rashidi A.M., Synthesis of ZnO Nanoparticles by Spray Pyrolysis Method, Iranian Journal Chemistry and Chemical Engineering (IJCCE), 30: 1-6 (2011). 

[16]  Chan H.-K., Kwok Ph.Ch.L., Production Methods for Nanodrug Particles Using the Bottom-Upapproach,Advanced Drug Delivery Reviews, 63: 406-416 (2011).

[17] Zhang H.-X., Wang J.-X., Shao L., Chen J.-F., Microfluidic Fabrication of Monodispersed Pharmaceutical Colloidal Spheres of Atorvastatin Calcium with Tunable Sizes, Industrial and Engineering Chemistry Research, 49: 4156-4161 (2010).

[18] Zabihi F., Akbarnejad M.M., Vaziri Yazdi A., Arjomand M., Safekordi A.A., Drug Nano-Particles Formation by Supercritical Rapid Expansion Method; Operational Condition Effects Investigation, Iranian Journal Chemistry and Chemical Engineering (IJCCE), 30: 7-15 (2011). 

[19] Dong Y., Ng W.K., Hu J., Shen Sh., Tan R.B.H., A Continuous and Highly Effective Static Mixing Process for Antisolvent Precipitation of Nanoparticles of Poorly Water-Soluble Drugs, International Journal of Pharmaceutics, 386: 256-261 (2010).

[20] Wang Z., Chen J.-F., Le Y., Shen Z.-G.,Preparation of Ultrafine Beclomethasone Dipropionate Drug Powder by Antisolvent Precipitation, Industrial and Engineering Chemistry Research, 46: 4839-4845 (2007).

[21] Dong Y., Ng W.K., Shen Sh., Kim S., Tan R.B.H., Preparation and Characterization of Spironolactone Nanoparticles by Antisolvent Precipitation, International Journal of Pharmaceutics, 375: 84-88 (2009).

[23] S.M. Ali H., York P., M.A. Ali A., Blagden, N., Hydrocortisone Nanosuspensions for Ophthalmic Delivery: A Comparative Study between Microfluidic Nanoprecipitation and Wet Milling, Journal of Controlled Release, 149: 175-181 (2011).

[24] El-Gendy N., L. Aillon K., Berkland C., Dry Powdered Aerosols of Diatrizoic Acid Nanoparticle Aglomerates as a Lungcontrast Agent, International Journal of Pharmaceutics, 39: 305-312 (2010).

[25] Matteucci M.E., Hotze M.A., Johnston K.P., Williams R.O., Drug Nanoparticles by Antisolvent Precipitation: Mixing Energy Versus Surfactant Stabilization, Langmuir, 22: 8951-8959 (2006).