Department of Chemistry, Faculty of Science, Tehran University, Tehran, I.R. IRAN
10.30492/ijcce.1993.10929
Abstract
Using a-tetralone, as starting material, a series of phencyclidine analogues were synthesized. This ketone was reacted separately with ethylmagnesium bromide, P-methoxyphenylmagnesium bromide and P-methylphenylmagnesium bromide. The resultant alcohols were treated with a suspension of NaN3 and CCl3COOH in CHCl3. The azides were subsequently reduced with LiAlH4 in dry ether to their primary amines. Cyclization of these amines with 1,5-dibromopentane and 1,4- dibromobutane gave tertiary amines.
Darvich, M. R., & Zonoozi, A. (1993). Preparation of the Phencyclidine Analogues (Part II). Iranian Journal of Chemistry and Chemical Engineering, 12(1), 17-21. doi: 10.30492/ijcce.1993.10929
MLA
Mohammad Raouf Darvich; Afsaneh Zonoozi. "Preparation of the Phencyclidine Analogues (Part II)". Iranian Journal of Chemistry and Chemical Engineering, 12, 1, 1993, 17-21. doi: 10.30492/ijcce.1993.10929
HARVARD
Darvich, M. R., Zonoozi, A. (1993). 'Preparation of the Phencyclidine Analogues (Part II)', Iranian Journal of Chemistry and Chemical Engineering, 12(1), pp. 17-21. doi: 10.30492/ijcce.1993.10929
VANCOUVER
Darvich, M. R., Zonoozi, A. Preparation of the Phencyclidine Analogues (Part II). Iranian Journal of Chemistry and Chemical Engineering, 1993; 12(1): 17-21. doi: 10.30492/ijcce.1993.10929