Conversion of Alcohols into Amides Using Alumina-Methanesulfonic Acid (AMA) in Nitrile Solvents

Document Type: Research Article

Authors

Department of Chemistry, Shiraz University, Zip code 71454, Shiraz, I.R. IRAN

Abstract

The reaction of tertiary, secondary and benzylic alcohols with different nitriles in the presence of alumina-methanesulfonic acid (AMA) as a new reagent affords the corresponding amides in good yields (Table 1, 2). Conversion of 2,6-bis(hydroxymethyl)-4-halo anisoles into corresponding diamides in the range of 68-76% yields (Table 3) are also included in this paper.

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