Synthesis and X-Ray Structural Determination of 2,4,6,8- Tetraphenyl- 2,4,6,8- Tetraazabicyclo [3.3.0] Octane

Document Type: Research Article

Authors

1 Department of Chemistry, Faculty of Sciences, University of Tehran, Tehran, I.R. IRAN

2 Department of Chemistry, Faculty of Sciences,University of Tehran , Tehran, I.R. IRAN

3 Department of Chemistry, Hunter College, New York, New York, 10021, USA

4 Hoffmann-LaRoche Inc. Nutley, New Jersey 07110-1199, USA

Abstract

Condensation of glyoxal, formaldehyde and anilines lead to the formation of 2,4,6,8- tetraphenyl and substituted phenyl 2,4,6,8-tetraazabicyclo [3.3.0] octanes. The reactions are sensitive to pH and temperature. Ortho derivatives of anilines do not participate in this condensation. X-ray structural determination reveals a cis-dienvelope geometery about the two fused rings.

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