Bromination and Dehydrobromination Studies on Some CIS-4a-Methyl-Decaline-2,7-Diones

Document Type: Research Article


1 CUNY Graduate Center, Department of Chemistry, Hunter College, New York, N.Y. 10021, USA

2 Research Division, Hoffimann-La Roche, Inc., Nutly, NJ 07110, USA


Results of the bromination and dehydrobromination of several angular methylated decalindiones are described. The key reaction, base-induced cyclization of the monobromo keto ester (3), and the dibromo ketone (4), leads to the formation of tricyclic systems (6) and (9) respectively.


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