Selective Mono Bromination of 1,4-Dihydropyridines

Document Type : Research Article

Authors

Organic Synthesis Research Lab., Faculty of Chemistry, Tabriz University, Zip code 51664, Tabriz, I.R. IRAN

10.30492/ijcce.1997.10330

Abstract

2-monobromomethyl 1,4-dihydropyridines is selectively synthesized by bromination of the parent compound by 1.1 equivalents of pyridinium bromide perbromide in dichloromethane/pyridine at -20 °C. The same reagent in dichloromethane at 0 °C produce the 2,6-bis(bromomethyl) 1,4-dihydropyridines.

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