A Facile One-Pot Synthesis of Functionalized N-Hydroxypyrrole Mediated by Vinyl-Triphenylphosphonium Salt

Document Type: Research Note

Authors

1 Department of Chemistry, Tarbiat Modares University, P.O. Box 14155-4838, Tehran, I.R. IRAN

2 Department of Chemistry, Tarbiat Modarres University, P.O. Box 14155-4838, Tehran, I.R. IRAN

3 Department of Chemistry, Islamic Azad University, Science and Research Campus, Tehran, I.R. IRAN

Abstract

Protonation of the reactive intermediates generated in the raction between dalkyl acetylenedicarboxylates and triphenylphosphine by isonitrosoacetophenone leads to vinyltriphenylphosphonium salts, which undergo intramolecular Wittig reaction to produce dalkyl 4-phenyl-N-hydroxypyrrole-2,3-dicarboxylates in moderate yields.

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