Nitroimidazoles XIII. Synthesis of Substituted (1-Methyl-5-Nitro-2-Imidazolyl) Isoxazoles

Document Type : Research Article

Authors

Department of Chemistry, Faculty of Pharmacy, The Medical Science University of Tehran, Zip code 14174, Tehran, I.R. IRAN

10.30492/ijcce.1998.10300

Abstract

The beta0diketone derivatives of nitroimidazole were synthesized from the reaction of magnesium salt of beta-ketoaccids 3 with imidazolide 4. The raction of beta-diketones with hydroxylamine hydrochloride afforded either the isoxazoles or the 5-hydroxyl-2-isoxazolines.

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