A Reinvestigation of Nitration of Phenols with Metal Nitrates under Non-Aqueous and Aprotic Conditions

Document Type: Research Article

Authors

Department of Chemistry, Faculty of Science, Shiraz University, Zip code 71454, Shiraz,, I.R. IRAN

Abstract

Nitration of phenol and various 4-substituted phenols with Cu(NO3)2.3H2O, Cu(NO3)2.3H2O/SiO2, 9H2O and Cr(NO3)2. 9H2O in different anhydrous organic solvents are investigated. High selectivity ratio of para vs ortho isomers has been observed. Mono- and dinitro compounds from phenol and 4-substituted phenols by choosing the proper solvents and reaction conditions, are also obtained with high selectivity in excellent yields. Rate enhancement for mononitration of phenols in the presence of LiClO4 with Cu(NO3)2.3H2O is observed. 

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