TY - JOUR ID - 9624 TI - Influence of Formulation Parameters on the Release of Diclofenace Sodium from Matrices with Manufacturing Formulation Ingredients JO - Iranian Journal of Chemistry and Chemical Engineering JA - IJCCE LA - en SN - 1021-9986 AU - Abdekhodaie, Mohammad Jafar AU - Hemmati, Ali Asghar AD - Department of Chemical Engineering, Sharif University of Technology, P.O. Box 11365-8639 Tehran, I.R. Iran Y1 - 2002 PY - 2002 VL - 21 IS - 2 SP - 135 EP - 140 KW - Diclofenac sodium KW - Cetyl alcohol KW - Fractional release profile KW - Manufacturing formulation DO - 10.30492/ijcce.2002.9624 N2 - Effects of formulation parameters on the fractional release profile of diclofenac sodium from matrices having the manufacturing formulation ingredients are studied. As a content of cetyl alcohol (rate controlling agent) in the matrix increases, the fractional release decreases. The fractional release increases either by increasing sucrose content outside the granule or by decreasing sucrose content inside the granule. Results presented here indicate that as PVP content outside the granule or aerosol fraction inside or outside the granule in the matrix increases, the fractional release increases. The fractional release profiles of diclofenac sodium from matrices, when each ingredient is inside or outside, or half inside - half outside the granule, are compared. UR - https://ijcce.ac.ir/article_9624.html L1 - https://ijcce.ac.ir/article_9624_9af77547de331ae36977510c92acc61d.pdf ER -