TY - JOUR ID - 34239 TI - Synthesis, Reactions and Antioxidant Activity of 5-(3', 4'-dihydroxy-tetrahydrofuran-2'-yl)-2-methyl-3-carbohydrazide JO - Iranian Journal of Chemistry and Chemical Engineering JA - IJCCE LA - en SN - 1021-9986 AU - El Sadek, Mohamed AU - Magd, Samir Ahmed AU - Hassan, Seham Yassen AU - Mostafa, Mohamed A. AU - Yacouat, Galile AD - Chemistry Department, Faculty of Science, Alexandria University, Alexandria 21231, EGYPT AD - Biochemistry Department, Faculty of Science, Alexandria University, Alexandria 21231, EGYPT Y1 - 2019 PY - 2019 VL - 38 IS - 6 SP - 229 EP - 242 KW - carbohydrazides KW - bisaroylhydrazones KW - 1, 3, 4-oxadiazoles DO - 10.30492/ijcce.2019.34239 N2 - In this manuscript, we describe the synthesis of the carbohydrazide 2. Acid-catalyzed condensation with several carbonyl compounds to afford the corresponding carbohydrazide derivatives 3-12. Their acetylation afforded the corresponding acetyl derivatives 13-22. Oxidative cyclization of O-acetyl derivatives 19-22 afforded the corresponding 1,3,4-oxadiazole derivatives 23-26. On the other hand, condensation of the dicarbonyl compound 27 with several aroylhydrazines to give the corresponding bisaroylhydrazones 28-32 cyclization of 28-31 afforded 1,3,4-oxadiazoles 33-36. The structures of the prepared compounds were confirmed by 1HNMR and Mass Spectra. The mechanism of the formation of the products was discussed. Furthermore, the antioxidant activities of some of the prepared compounds were examined. UR - https://ijcce.ac.ir/article_34239.html L1 - https://ijcce.ac.ir/article_34239_891490bd5bc928a86e0569172e428fa2.pdf ER -