TY - JOUR ID - 34238 TI - Synthesis, Characterization, Molecular Docking and Cytotoxicity Studies of Bagasse Xylem Ferulate-Acrylamide/Methyl Methacrylate Composite JO - Iranian Journal of Chemistry and Chemical Engineering JA - IJCCE LA - en SN - 1021-9986 AU - Zuo, Kai AU - Qian, Jingxia AU - Gong, Jun AU - Zhang, Jun AU - Li, Heping AU - Zhou, Guoyong AD - College of Chemistry and Bioengineering, Guilin University of Technology, Guilin 541006, Guangxi, P.R. CHINA AD - School of Chemistry and Eco-Environmental Engineering (School of Chinese Pharmacy), Guizhou Minzu University, Guiyang 550025, Guizhou, P.R. CHINA Y1 - 2019 PY - 2019 VL - 38 IS - 3 SP - 107 EP - 116 KW - Bagasse Xylem Ferulate-Acrylamide/Methyl Methacrylate KW - Synthesis KW - Characterization KW - Cytotoxicity KW - Molecular Docking DO - 10.30492/ijcce.2019.34238 N2 - BXFL (bagasse xylem ferulate)-g-AM (acrylamide)/MAA (methyl methacrylate) was synthesized based on bagasse xylan(BX)-g-AM/MAA in 1-Butyl-3-methylimidazolium chloride ([Bmim] Cl) ion solution with Ferulic Acid (FL) as esterification agent. The various factors that were investigated influenced carboxylic acid ester substitution degree (DSC) of BXFL-g-AM/MAA. The structures of BXFL-g-AM/MAA were confirmed by IR, SEM and 1H NMR analysis. The cytotoxicity of BXFL-g-AM/MAA was investigated against twelve kinds of protein through Surflex-Dock Mode of Sybyl-X 2.0 software, and on three kinds of human cancer cells line and the human normal cells line were detected by MTT assay. It was shown that the maximum DSC was 1.09 in ion solution, which was superior to DSC of conventional method in organic solvent. The results of MTT assay were consistent with docking results. BXFL-g-AM/MAA exhibited relative high cytotoxicity against human gastric cancer cells (MGC-803) line. UR - https://ijcce.ac.ir/article_34238.html L1 - https://ijcce.ac.ir/article_34238_cc5f52b2c134d1afc1eb4d44d8163209.pdf ER -