TY - JOUR ID - 28213 TI - Pseudo-Five-Component Condensation for the Diversity-Oriented Synthesis of Novel Indoles and Quinolines Containing Pseudo-Peptides (Tricarboxamides) JO - Iranian Journal of Chemistry and Chemical Engineering JA - IJCCE LA - en SN - 1021-9986 AU - Shiri, Morteza AU - Mohamed Heravi, Majid AU - Zadsirjan, Vahideh AU - Nejatinezhad-Arani, Atefeh AU - Shintre, Suhas Ashok AU - Koorbanally, Neil Anthony AD - Department of Chemistry, Faculty of Science, Alzahra University, Tehran, I.R. IRAN AD - School of Chemistry and Physics, University of KwaZulu-Natal, Private Bag X54001, Durban, 4000, SOUTH AFRICA Y1 - 2018 PY - 2018 VL - 37 IS - 4 SP - 101 EP - 115 KW - 2-formylindole KW - 2-chloro-3-formyl quinolone KW - isocyanides KW - Meldrum’s acid KW - multicomponent reaction KW - tricarboxamide DO - 10.30492/ijcce.2018.28213 N2 - A novel series of indole and quinoline tricarboxamides were synthesized using simple and efficient one-pot pseudo-five-component reactions of 2-formylindole or 2-chloro-3-formyl quinolines, isocyanides, amines, and Meldrum’s acid as a CH-acid in CH2Cl2 at room temperature. This conversion has been achieved via the construction of new bonds including two C-C bonds, two C-N bonds, and one C=O bond. Remarkably, three peptide bonds were formed through a domino sequence including Knoevenagel reaction, [1+4] cycloaddition, deacetonation and also, aminolysis reaction. Particularly, a number of structurally remarkable and pharmacologically significant products were provided in excellent yields. UR - https://ijcce.ac.ir/article_28213.html L1 - https://ijcce.ac.ir/article_28213_fe78afbfbacb0eb77ccffc182226c60b.pdf ER -